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Prof. Punna Rao Ravi

Professor
Department of Pharmacy

Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India

About the Faculty

 Academic Qualifications

Ph.D. (Pharmaceutics)

BITS-Pilani, Pilani Campus

2008

M. Pharm (Pharmaceutics)

BITS-Pilani, Pilani Campus

2002

B. Pharm

BITS-Pilani, Pilani Campus

2000

 

Professional Experience 

 Professor BITS-Pilani, Hyderabad Campus June 2021 - till date

Associate Professor

BITS-Pilani, Hyderabad Campus

Feb 2015 – May 2021

Assistant  Professor

BITS-Pilani, Hyderabad Campus

July 2009 – Jan 2015

Assistant  Professor

BITS-Pilani, Pilani  Campus

Aug 2008 – June 2009

Lecturer

BITS, Pilani, Pilani Campus

June 2003 – July 2008

Asst. Lecturer

BITS, Pilani, Pilani Campus

June 2002 – May 2003

Project Asst.

BITS, Pilani, Pilani Campus

June 2000 – May 2002

 Professional Experience and Training

·       Involved in research from 2001

·       Involved in teaching from 2002

·       Worked as Project Student in Formulation Development Division at Cadila Pharmaceuticals Ltd., Ahmedabad, Gujarat from June 1999 – December 1999.

·       Worked as Project Student in Formulation Development and Analytical Division at Parke Davis India Pvt. Ltd., Hyderabad, Andhra Pradesh from May 1998 – July 1999.

 

 

Courses

Higher Degree Courses

          Pharmacokinetics and Clinical Pharmacy
           Dosage Form Design
           Advanced Drug Delivery Systems
           Pharmaceutical Biostatistics
          Quality by Design in Pharmaceutical Product Development
 

First Degree Courses

           Industrial Pharmacy
          Pharmaceutical Formulations and Biopharmaceutics
          Process Engineering
          Pharmaceutical Unit Operations - I 
           Pharmaceutical Unit Operations - II

Work Integrated Learning Program (WILP) Courses

The following short term courses were designed and are being taught to executives of Sun Pharmaceutical Industries Ltd.:

          Biostatistics
          Pharmacokinetics
          Design of Experiments (DoE) 
          Biopharmaceutics

 

Research Team

Ph.D. Students (Currently Pursuing Ph.D.)

1. Ms. Ekta Prasanthi Bommireddy, M Pharm

Institute Fellowship

E-mail: p20150415@hyderabad.bits-pilani.ac.in

2. Mr. Radhakrishna Mullapudi TV, M Pharm (Part-time PhD student)

E-mail: krishna.mullapudi@acubiosys.com

3. Mr. Pradeep Singh Rawat, M Pharm (Part-time PhD student)

E-mail: pradeep.rawat@sandoz.com

4. Mr. Mohammed Shareef Khan, M Pharm

Lady Tata Memorial Trust – Junior Research Fellow

E-mail: mdkhanshareef@gmail.com

5. Ms. Radhika Rajiv Mahajan, M Pharm

DST Inspire Fellowship

E-mail: p20200469@hyderabad.bits-pilani.ac.in

6. Mr. Swagata Sinha

Research Fellow

 
Ph.D. Awarded
 

1. Dr. Aditya.N, M Pharm, Ph.D.

E-mail: adityamurthy1212@gmail.com

2. Dr. Rahul Vats, M Pharm, Ph.D.

E-mail: rahulvats1983@gmail.com

3. Dr. Shailender Joseph, M Pharm, Ph.D.
CSIR – Senior Research Fellow

E-mail: shailender.joseph@gmail.com

4. Dr. Mrs. Rashmi Nair, M Pharm, Ph.D.

E-mail: rashmin@drreddys.com

5. Dr. Rimpy Diwan, M Pharm, Ph.D.

DST Inspire Fellowship

E-mail: rmpdiwan@gmail.com

6. Dr. Dalvi Avantika Vijay, M Pharm, Ph.D.

Indian Council of Medical Research (ICMR) – Senior Research Fellow

E-mail: avantidalvi@gmail.com

7. Dr. Chandra Teja Uppuluri, M Pharm, Ph.D.

Lady Tata Memorial Trust – Senior Research Fellow

E-mail: u.chandrateja@gmail.com
 
8. Mr. Ravi Kiran Panchakarla (final viva-voce pending)

 

 

Sponsored Projects

 Ongoing Research Projects:

 

Sl No.

Title of Project

Funding Agency

Amount (Rs)

Date of sanction and Duration

1

Evaluation of Novel Transdermal Device for Controlled Delivery of a Drug

Medicen Devise Technologies Pvt. Ltd., Hyderabad

Rs 18.7 Lakhs

Nov 2020, 1.5 Years

2

Design and Evaluation of Novel Transdermal Drug Delivery Systems

Transform SciTech Pvt. Ltd., Hyderabad

Rs 19.1 Lakhs

Nov 2020, 2 Years

3

Drug Metabolism and Pharmacokinetic Studies     

Acubiosys Pvt.  Ltd., Hyderabad

Rs 10 Lakhs

 August 2017, 3 Years

    

     Completed Research Projects:

Sl No.

Title of Project

Funding Agency

Amount

Date of sanction and Duration

1

Technical and Knowledge Support for Preparation and Filing of Drug Master File (DMF) as per Common Technical Document (CTD) for Sennosides USP including the Analytical Requirements

Shasi Phytochemicals Ltd., Alwar, Rajasthan

5.74 Lakhs

September 2016, 2 Years

2

Design, Characterization and Pharmacokinetic Evaluation of Nanocarriers for Antiretroviral Drug Delivery in the Effective Treatment of HIV/AIDS  

DST

23.10 Lakhs

April, 2012; 3 years

3

Design, Pharmacokinetic and Pharmacodynamic Evaluation of Nanocarriers for Selective Estrogen Receptor Modulators (SERMs) Delivery in the Effective Treatment of Post-menopausal Osteoporosis

UGC, New Delhi

7.83 Lakhs

Feb 2011; 3 years

4

Preformulation and oral pharmacokinetic studies of Rifaximin    

Daewoong Pharmaceuticals Ltd., Hyderabad

5.79 Lakhs

 1 Year

5

In-vivo evaluation of Nasal Moisturizer

TTK LIG Ltd., Chennai

50,000

1 week

6

Development of a Stable Formulation for Selected Combination of Drugs

IPCA Laboratories Ltd., Mumbai

11 Lakhs

2 years

7

GMP System Implementation in Production Facility at Shashi Phytochemical Industries

Sashi Phytochemicals Ltd., Alwar, Rajasthan

4 Lakhs

6 months

 

 

 

Publications

Peer Reviewed Journal Publications

  1.  Chandra Teja Uppuluri, Punna Rao Ravi, Avantika V. Dalvi. Design, Optimization and Pharmacokinetic Evaluation of Piribedil Loaded Solid Lipid Nanoparticles Dispersed in Nasal In Situ Gelling System for Effective Management of Parkinson’s Disease. International Journal of Pharmaceutics; 2021,606, 120881; DOI: 10.1016/j.ijpharm.2021.120881. (IF 5.88)

  2. Avantika V. Dalvi, Punna Rao Ravi, Chandra Teja Uppuluri. Rufinamide-Loaded Chitosan Nanoparticles in Xyloglucan-Based Thermoresponsive In Situ Gel for Direct Nose to Brain Delivery. Frontiers in Pharmacology; 2021, 51, 199-211; DOI: 10.3389/fphar.2021.691936. (IF 5.81)
  3. Avantika V. Dalvi, Punna Rao Ravi, Chandra Teja Uppuluri, Radhika R. Mahajan, Sumeet V. Katke, Vibha S. Deshpande. Thermosensitive nasal in situ gelling systems of rufinamide formulated using modified tamarind seed xyloglucan for direct nose-to- brain delivery: design, physical characterization, in vivo evaluation. Journal of Pharmaceutical Investigation; 2021, 51, 199-211; DOI: 10.1007/s40005-020-00505-9. (IF 3.22)
  4. Rimpy Diwan, Punna Rao Ravi, Shubham Ishwar Agarwal, Vidushi Aggarwal. Cilnidipine loaded poly (ε-caprolactone) nanoparticles for enhanced oral delivery: Optimization using DoE, physical characterization, pharmacokinetic and pharmacodynamic evaluation. Pharmaceutical Development and Technology; 2021, 26(3), 278-290; DOI: 10.1080/10837450.2020.1864643. (IF 2.35)
  5. Aditya N Murthy, Punna Rao Ravi, Himanshu Kathuria, Srinivas Malekar. Oral Bioavailability Enhancement of Raloxifene with Nanostructured Lipid Carriers. Nanomaterials (MDPI), 2020, 10(6), 1085; https://doi.org/10.3390/nano10061085. (IF 4.03)
  6. Aditya N Murthy, Punna Rao Ravi, Himanshu Kathuria, Rahul Vats. Self-assembled lecithin-chitosan nanoparticles improve the oral bioavailability and alter the pharmacokinetics of raloxifene. International Journal of Pharmaceutics (Elsevier), 2020, 588(15), 119731; https://doi.org/10.1016/j.ijpharm.2020.119731. (IF 4.85)
  7. Chandra Teja Uppuluri, Punna Rao Ravi, Avantika V. Dalvi, Shafik Shakil Shaikh, Suvarna R. Kale. Piribedil loaded thermo-responsive nasal in situ gelling system for enhanced delivery to the brain: formulation optimization, physical characterization, and in vitro and in vivo evaluation. Drug Delivery and Translational Research (Springer Nature), 2020. https://doi.org/10.1007/s13346-020-00800-w. (IF 3.3)
  8. Rimpy Diwan, Punna Rao Ravi, Nikita Shantaram Pathare, Vidushi Aggarwal. Pharmacodynamic, pharmacokinetic and physical characterization of cilnidipine loaded solid lipid nanoparticles for oral delivery optimized using the principles of design of experiment. Colloids and Surfaces B: Biointerfaces (Elsevier Science Ltd., England), 2020. https://doi.org/10.1016/j.colsurfb.2020.111073. (IF 4.1)
  9. Rimpy Diwan, Shareef Khan, Punna Rao Ravi. Comparative study of cilnidipine loaded PLGA nanoparticles: process optimization by DoE, physico-chemical characterization and in vivo evaluation. Drug Delivery and Translational Research (Springer Nature), 2020. https://doi.org/10.1007/s13346-020-00732-5. (IF 3.3)
  10. Pradeep Singh Rawat, Punna Rao Ravi, Laxman Kaswan, Rajeev Singh Raghuvanshi. Development and validation of a bio-analytical method for simultaneous quantification of nebivolol and labetalol in aqueous humor and plasma using LC-MS/MS and its application to ocular pharmacokinetic studies. Journal of Chromatography B (Elsevier), 2020. https://doi.org/10.1016/j.jchromb.2019.121908. (IF 2.81).
  11. Ravi Kiran Panchakarla, Punna Rao Ravi, Kondapalli Venkata Gowri Chandra Sekhar. Selective and Sensitive UHPLC Method for the Trace Analysis of Formaldehyde in Drug Substance Using Fused-core Column Technology and Detailed Pre-column Derivatization study. Current Pharmaceutical Analysis. (Bentham Science), 2019. DOI: 10.2174/1573412916666191116115424 (e-print). (IF 0.9)
  12. Avantika V. Dalvi, Chandra Teja Uppuluri, Ekta Prasanthi Bommireddy, Punna Rao Ravi. Design of experiments-based RP – HPLC bioanalytical method development for estimation of Rufinamide in rat plasma and brain and its application in pharmacokinetic study. Journal of Chromatography B (Elsevier Science Ltd., England), 1102-1103: 74-82, 2018. (IF 2.44)
  13. Chandra Teja Uppuluri, Avantika V. Dalvi, Ekta Prasanthi Bommireddy, Punna Rao Ravi. Development and validation of rapid and sensitive LC methods with PDA and fluorescence detection for determination of piribedil in rat plasma and brain tissues and their pharmacokinetic application. Biomedical Chromatography (John Wiley & Sons, Inc.), 32(10), 2018 (IF 1.69)
  14. Shailender Joseph, Punna Rao Ravi, Reddy Sirukuri Mrinalini, Dalvi Avantika,  Keerthi Priya Odapalli. Chitosan nanoparticles for the oral delivery of tenofovir disoproxil fumarate: formulation optimization, characterization and ex vivo and in vivo evaluation for uptake mechanism in rats. Drug Dev. Ind. Pharm. (Informa Healthcare, USA), 26: 1-11, 2018. (IF 2.43)
  15. Nair R, Lamare I, Tiwari NK, Punna Rao Ravi, Pillai R. In Situ Salification in Polar Solvents: A Paradigm for Enabling Drug Delivery of Weakly Ionic Drugs as Amorphous Solid Dispersion. AAPS PharmSciTech (Springer). 19(1): 326-37, 2017. (IF 1.95)
  16. Shailender Joseph, Punna Rao Ravi, Saha Paramita, Dalvi Avantika, Myneni Srividya. Tenofovir disoproxil fumarate loaded PLGA nanoparticles for enhanced oral absorption: Effect of experimental variables and in-vitro, ex-vivo and in-vivo evaluation. Colloids and Surfaces B: Biointerfaces (Elsevier Science Ltd., England), 158: 610-9, 2017. (IF 4.1)
  17. Joseph Shailender, Punna Rao Ravi, Paramita Saha, Srividya Myneni. Oral Pharmacokinetic Interaction of Ester Rich Fruit Juices and Pharmaceutical Excipients with Tenofovir Disoproxil Fumarate in Male Wistar Rats. Xenobiotica (Informa Healthcare, England), 12: 1-8, 2017. (IF 1.72)
  18. Punna Rao Ravi, Vats Rahul. Comparative pharmacokinetic evaluation of lopinavir and lopinavir‐loaded solid lipid nanoparticles in hepatic impaired rat model. Journal of Pharmacy and Pharmacology (John Wiley & Sons, Inc.), 26(7): 823-33, 2017. (IF 2.36)
  19. Punna Rao Ravi, S. Joseph, U.S.R. Avula, S. Anthireddy. A Simple Liquid Chromatographic Method for the Determination of Tenofovir in Rat Plasma and Its Application to Pharmacokinetic Studies. Acta Chromatographica (Akademiai Kiado RT, Poland), 27(4): 597–612, 2015. (IF 0.523)
  20. Punna Rao Ravi, Rahul Vats, Vikas Dalal, Nitin Gadekar, Aditya N. Design, Optimization and Evaluation of Poly-e-Caprolactone (PCL) Based Polymeric Nanoparticles for Oral Delivery of Lopinavir. Drug Dev. Ind. Pharm. (Informa Healthcare, USA), 41(1): 131–140, 2015. (IF 2.429)
  21. Punna Rao Ravi, R. Vats, S. Joseph, N. Gadekar. Development and Validation of Simple, Rapid and Sensitive LC-PDA Ultraviolet Method for Quantification of Nebivolol in Rat Plasma and its Application to Pharmacokinetic Studies. Acta Chromatographica (Akademiai Kiado RT, Poland), 27(2): 281–294, 2015. (IF 0.523)
  22. Punna Rao Ravi, N. Aditya, S. Patil, L. Cherian. Nasal In-Situ Gels for Delivery of Rasagiline Mesylate: Improvement in Bioavailability and Brain localization. Drug Deliv. (Informa Healthcare, USA), 22(7): 903-10, 2015. (IF 4.843)
  23. Punna Rao Ravi, Rahul Vats, Jagadeesh Balija, Sathya Prabhu Naidu Adapa, N. Aditya. Modified Pullulan Nanoparticles for Oral Delivery of Lopinavir: Formulation and Pharmacokinetic Evaluation. Carbohydrate Polymers (Elsevier Science Ltd., England), 110: 320–328, 2014. (IF 4.219)
  24. N. Aditya, Punna Rao Ravi, Uday Sai Ranjan Avula, Rahul Vats. Poly (e-Caprolactone) Nanocapsules for Oral Delivery of Raloxifene: Process Optimization by Hybrid Design Approach, In Vitro and In Vivo Evaluation. J Microencapsul. (Informa Healthcare, England), 31(5): 508–518, 2014. (IF 1.585)
  25. Punna Rao Ravi, Rahul Vats, Vikas Dalal and Aditya Narasimha Murthy. A Hybrid Design to Optimize Preparation of Lopinavir Loaded Solid Lipid Nanoparticles and Comparative Pharmacokinetic Evaluation with Marketed Lopinavir/Ritonavir Coformulation. J Pharm Pharmacol. (Wiley-Blackwell, England), 66(7): 912-26, 2014. (IF 2.363)
  26. Punna Rao Ravi, N. Aditya, Himanshu Kathuria, Srinivas Malekar, Rahul Vats. Lipid nanoparticles for oral delivery of raloxifene: Optimization, stability, in vivo evaluation and uptake mechanism. European Journal of Pharmaceutics and Biopharmaceutics (Elsevier Science BV, Netherlands), 87: 114–124, 2014. (IF 3.975)
  27. Punna Rao Ravi, N. Aditya, L. Cherian, S. Patil. LC Method for Determination of Rasagiline Mesylate in Different Plasma Matrices and its Application to Oral Pharmacokinetic Study in Rabbits. Journal of Chromatographic Science (Oxford Univ. Press Inc., USA), 51(1):1–7, 2013. (IF 1.32)
  28. Punna Rao Ravi, Rahul Vats, Upendra Reddy Kora. Effect of Ciprofloxacin and Grapefruit Juice on Oral Pharmacokinetics of Riluzole in Wistar Rats Journal of Pharmacy and Pharmacology (Wiley-Blackwell, England), 65: 337–344, 2013. (IF 2.363)
  29. Punna Rao Ravi, N. Aditya, R. Vats. Development, Validation, and Pharmacokinetic Application of Liquid Chromatographic Method for Estimation of Raloxifene Hydrochloride in Rabbit Plasma. Acta Chromatographica (Akademiai Kiado RT, Poland), 24(4): 559–573, 2012. (IF 0.523)
  30. Punna Rao Ravi, R. Vats, R. Thakur, S. Srivani, N. Aditya. Effect of Grapefruit Juice and Ritonavir on Pharmacokinetics of Lopinavir in Wistar Rats. Phytother. Res. (John Wiley & Sons, Inc.), 26(10): 1490-5, 2012. (IF 2.694)
  31. Validation of a Simple, Rapid and Sensitive LC Method for Quantification of Riluzole in Rat Plasma and its Pharmacokinetic Application. J. Bioanal. Biomed. (2012) S6: 007. doi:10.4172/1948-593X.S6-007.
  32. Rahul Vats, Aditya Narasimha Murthy, Punna Rao Ravi. Simple, Rapid and Validated LC Determination of Lopinavir in Rat Plasma and its Application in Pharmacokinetic Studies. Sci. Pharm, 79: 849–863, 2011. (Open Access)
  33. Sajeev Chandran, Punna Rao Ravi, Pravin R. Jadhav, Ranendra N. Saha. Simple rapid validated LC method for the estimation of nimesulide in human serum and its application in bioavailability studies. Analytical Letters (Taylor & Francis Online), 41(13): 2437-2451, 2008. (IF 1.20)
  34. Punna Rao Ravi, Udaya Kant Kotreka, Ranendra N. Saha. Controlled release matrix tablets of zidovudine: Effect of formulation variables on the in vitro drug release kinetics. AAPS PharmSciTech (Springer), 9: 302-313, 2008. (IF 1.95)
  35. Punna Rao Ravi, Sindhura G., Ranendra N. Saha. Design and in vitro evaluation of zidovudine oral controlled release tablets prepared using hydroxypropyl methylcellulose. Chem. Pharm. Bull. (The Pharmaceutical Society of Japan), 56: 518-524, 2008. (IF 1.42)
  36. Punna Rao Ravi, Sindhura G., Ranendra N. Saha; Design and study of lamivudine oral controlled release tablets. AAPS PharmSciTech (Springer), 8(4): 167-175, 2007. (IF 1.95)
  37. Sajeev Chandran, Punna Rao Ravi, Ranendra N. Saha. Development and in vitro evaluation of oral controlled release formulations of celecoxib using optimization techniques. Journal of Pharmaceutical Society of Japan (Yakugaku Zasshi),126(7): 505-514, 2006. (Open Access)
  38. Ranendra N. Saha, Sajeev Chandran, Girish B., Punna Rao Ravi; Studies on design and evaluation of controlled release polymeric discs for ocular delivery of Flurbiprofen and Celecoxib. Indian Journal of Pharmaceutical Sciences (Medknow Publications & Media Pvt. Ltd.), 64(3): 325-326, 2002. (IF 0.762)

 

Journal Abstracts 

1.      Punna Rao Ravi, Udaya Kant Kotreka, Ranendra N. Saha. Design and evaluation of oral controlled release tablet formulations of Lamivudine prepared using Ethyl cellulose and Carbopol-971P. The AAPS Journal, 9(S2), 2007

2.      Punna Rao Ravi, R. Vats, K.U. Reddy. Validation of a Simple, Rapid and Sensitive LC Method for Quantification of Riluzole in Rat Plasma and its Pharmacokinetic Application. Journal of Bianalysis and Biomedicin. S6:007, 2012.

3.      Punna Rao Ravi, Udaya Kant Kotreka, Ranendra N. Saha. Design and evaluation of oral controlled release tablet formulations of Zidovudine prepared using Ethyl cellulose and Carbopol 971P. The AAPS Journal; 8(S2), 2006.

4.      Punna Rao Ravi, Sindhura G., Ranendra N. Saha. Design and evaluation of oral controlled release tablet formulations of Lamivudine. The AAPS Journal; 7(S2), 2005.

5.      Punna Rao Ravi, Amit Mishra, Ranendra N. Saha. Design of oral controlled release formulations of Zidovudine using hydroxypropyl methylcellulose based tablets. The AAPS Journal; 6(S1), 2004.

6.      Punna Rao Ravi, Ranendra N. Saha. A new rapid, simple and validated UV spectrophotometric method for estimation of Zidovudine in bulk, formulations and dissolution samples. The AAPS Journal; 6(S1), 2004.

 

Book Chapter

1.      Punna Rao Ravi, Sajeev Chandran. Application of polynomial & composite methods to optimize the design & development of controlled release oral drug delivery system; In: Mathematical Modeling- Application Issues & Analysis, Eds. Mishra BK., Satpathi DK,  Anne Books India, New Delhi, 2006, p15-21.