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Angshuman Sarkar

Professor

Cancer Biology, Cell and Molecular Biology, Nanotoxicology, Therapeutics
Department of Biological Sciences
BITS Pilani K K Birla Goa Campus
Chamber No. B213
NH17B Bypass Road
Zuarinagar 403 726
Goa

Recent Publications…

  1. Nivedita Kolvekar, Navodipa Bhattacharya, Sukanta Mondal, Angshuman Sarkar, Dibakar Chakrabarty. Daboialipase, a phospholipase A 2 from Vipera russelli russelli venom posesses anti-platelet, anti-thrombin and anti-cancer properties. Toxicon 239, 107632, 2024.

 

  1. Ravindran G, Samanta A and Sarkar A. Methylcobalamin Acts as a Synergistic Effector of Cadmium Chloride (Cdcl2) and Enhances Cadmium Induced Stress in Human A549 Cells through Methylation of MT2A Promoter, Adv. Clin Toxicol, 9 (1):291.1-10, 2024.

 

  1. Bhattacharya N, Kolvekar N, Mondal S, Sarkar A, Chakrabarty D. Biological activities of Vipegrin, an anti-adhesive Kunitz-type serine proteinase inhibitor purified from Russell's viper venom. Toxicon. 2023 Aug 15;232:107213.

 

  1. Mahajan M, Sarkar A, Mondal S. Cell cycle protein BORA is associated with colorectal cancer progression by AURORA-PLK1 cascades: a bioinformatics analysis. J Cell Commun Signal. 2023 Sep;17(3):773-791. doi: 10.1007/s12079-022-00719-6.

 

  1. Kapil Ganorkar, Angela Samanta, Soham Mukherjee,Ritika Joshi, Smruti Gupta, Angshuman Sarkarand Sujit Kumar Ghosh, Switching of the polarity-sensitive aggregation pattern of a thiosemicarbazone-based anticancer luminophore and Its involvement in cellular apoptosis of the human lung cancer cell line; Phys. Chem. B, 2023, 127, 1, 104–120.

 

  1. Kolvekar N, Bhattacharya N, Sarkar A, Chakrabarty D. How snake venom disintegrins affect platelet aggregation and cancer proliferation. Toxicon. 2023 Jan 1;221:106982. doi: 10.1016/j.toxicon.2022.106982. Epub 2022 Nov 23. PMID: 36435228.

 

  1. Bhattacharya N, Kolvekar N, Mondal S, Sarkar A, Chakrabarty D. SPAD-1, a serine proteinase associated disintegrin from Russell's viper venom disrupts adhesion of MCF7 human breast cancer cells. Toxicon. 2023 Jan 1;221:106979. doi: 10.1016/j.toxicon.2022.106979. 

 

  1. Kumar, A. Sarkar, Current therapeutic strategies and challenges in NSCLC treatment: a comprehensive review, Exp Oncol 2022 44, 1, 1–10; 10.32471/exp-oncology.2312-8852.vol-44-no-1.17411

 

  1. Makhan Kumar and Angshuman Sarkar. 2022. "Repurposing of Anti-Malarial Drug Quinacrine for Cancer Treatment: A Review" Scientia Pharmaceutica90, no. 1: 12. https://doi.org/10.3390/scipharm90010012

 

 

  1. Angela Samanta, Angshuman Sarkar, Altered expression of ERK, Cytochrome-c, and HSP70 triggers apoptosis in Quinacrine-exposed human invasive ductal carcinoma cells; Biomedicine & Pharmacotherapy 139, 2021, 111707, doi.org/10.1016/j.biopha.2021.111707.

 

  1. Angela Samanta, Geethanjali Ravindran and Angshuman Sarkar; Quinacrine causes apoptosis in human cancer cell lines through caspase-mediated pathway and regulation of small GTPase; Biosci, 2020, 45:43 DOI: 10.1007/s12038-020-0011-3.

 

  1. Makhan Kumar, Ansie Martin, Snehal Nirgude, Bibha Chaudhary, Sukanta Mandal and Angshuman Sarkar; Quinacrine inhibits GSTA1 activity and induces apoptosis through G1/S arrest and generation of ROS in human non-small cell lung cancer cell lines. Oncotarget. 2020 May 5; 11(18): 1603–1617.; DOI: 18632/oncotarget.27558.

 

  1. Mansi Baveja, Angshuman Sarkar, Sukanta Mondal, Jigni Pathan and Dibakar Chakrabarty; AiP1, a protein from the coelomic fluid of sea star Astropecten indicus promotes wound healing and fibrinogenolysis in vitro. The Journal of Basic and Applied Zoology, 2019; 80:50. https://doi.org/10.1186/s41936-019-0120-4.

 

  1. M Baveja, Sarkar and D Chakrabarty. Hemotoxic and wound healing potential of coelomic fluid of sea-star Astropecten indicus The Journal of Basic and Applied Zoology, (2019) 79:27 https://doi.org/10.1186/s41936-018-0038-2.

 

  1. Martin Ansie. & Sarkar Angshuman. (2018). In-vitro toxicity testing of nanomaterials. Cell Culture. IntechOpen. [Book Chapter].

 

  1. Ansie Martin and Angshuman Sarkar, Epithelial to Mesenchymal transition, eIF2alpha phosphorylation and Hsp70 expression enable greater tolerance in A549 cells to TiO2 over ZnO nanoparticles, Sci Rep. 2019 Jan 24;9(1):436. doi: 10.1038/s41598-018-36716-2.

 

  1. Ansie Martin and Angshuman Sarkar, Cellular migration as a Stress Relieving Strategy to Nanotoxicology, 2018, Int J cell Sci & Mol Biol. 2018; 4(2): 555634. DOI: 10.19080/IJCSMB.2018.04.555634002.

 

  1. Joshi RS, Mukherjee DD, Chakrabarty S, Martin A, Jadhao M, Chakrabarti G, Sarkar A, Ghosh SK. Unveiling the Potential of Unfused Bichromophoric Naphthalimide to Induce Cytotoxicity by Binding to Tubulin: Breaks Monotony of Naphthalimides as Conventional Intercalators. J Phys Chem B., Mar 21, 2018. doi: 10.1021/acs.jpcb.7b10429.

 

  1. Ansie Martin and Angshuman Sarkar, Overview on biological implications of metal oxide nanoparticle exposure to human alveolar A549 cell line. Nanotoxicology, 11(6):713-724, 2017.

 

  1. Akriti Rastogi, Angshuman Sarkar, Dibakar Chakrabarty, Partial purification and identification of a metalloproteinase with anticoagulant activity from Rhizostoma pulmo (Barrel Jellyfish), Toxicon, 132, 29-39, 2017.

 

  1. Jigni Pathan, Sukanta Mondal, Angshuman Sarkar, Dibakar Chakrabarty, Daboialectin, a C-type lectin from Russell's viper venom induces cytoskeletal damage and apoptosis in human lung cancer cells in vitro Toxicon, 127, 11-21 2017.

 

  1. Ravindran, D. Chakrabarty and A. Sarkar. Cell specific regulation of p53 mRNA expression induced by cadmium. Animal Cells and Systems (TACS) Dec. 2016, http://dx.doi.org/10.1080/19768354.2016.1267041.

 

  1. Chanda, A. Sarkar, D. Chakrabarty,  Thrombolytic protein from cobra venom with anti-adhesive properties. Arch. Biochem Biophys. 2016 Jan 10; 590:20-26.

 

  1. Pathan, A Martin, R. Chowdhury, D. Chakrabarty A. Sarkar, Russell's viper venom affects regulation of small GTPases and causes nuclear damage. Toxicon. 2015 Dec 15;108:216-25.

 

  1. Ravindran, D. Chakrabarty and A. Sarkar; Cadmium toxicity alters mRNA expression of Rho-like genes in A549 cell line.  Journal of Cell and Molecular Biology, Haliç University Press Publication, Vol. 11 (1 & 2):13-20, 2013

 

  1. Chanda, A. Sarkar, S. Sistla, and D. Chakrabarty; Anti-platelet activity of a three-finger toxin (3FTx) from Indian monocled cobra (Naja kaouthia) venom. Biochem Biophys Res Commun. 2013 Nov 22; 441 (3):550-4. doi: 10.1016/j.bbrc.2013.10.125. Epub. 2013 Oct 30.

 

  1. Sarkar A., Ravindran G. and Krishnamurthy V., A brief review on the effect of cadmium toxicity: from cellular to organ level. International Journal of Bio-Technology and Research (IJBTR) ISSN 2249-6858 Vol. 3, Issue 1, 2013, 17-36.

 

  1. Santimano M.C., Martin A., Kowshik M. and Sarkar A. Zinc Oxide Nanoparticles Cause Morphological Changes in Human A549 Cell Line Through Alteration in the Expression Pattern of Small GTPases at mRNA Level. Bionanosci. 7, 300-306, 2013.

 

  1. Rastogi, S. Biswas, A. Sarkar and D. Chakrabarty. Anticoagulant activity of Moon jellyfish (Aurelia aurita) tentacle extract. Toxicon. 2012 Oct; 60 (5):719-23.

 

  1. K. Sinha, K.P.Krishnan and A Sarkar, Heat shock response as a cue for phenotypic variability: A study from the psychrotrophic and mesophilic strains of Cellulosimicrobium cellulans; Annals of Microbiology, (DOI 10.1007/s13213-011-0411-6) 2012.

 

  1. Benjamin B Parrott, Yuting Chiang, Sarkar, A. Hudson, A. Guichet and C. Schulz, The Nucleoporin98-96 function is required for transit amplification divisions in the germ line of Drosophila melanogaster. PLoS One. 2011;6(9).

 

  1. Sarkar, N, Parikh, S. Hearn, M. T. Fuller, S. Tazuke and C. Schulz, Antagonistic roles of Rac and Rho in organizing the germ cell micro-environment. Current Biology, Vol. 17, 1253-1258, July 17, 2007* [‘Top 20 paper in USA’ selected in the year 2007].

 

  1. Sarkar and C. Schulz. An approach for Immufluoroscence of Drosophila S2 cells. CSHL Protocols, Vol. 2; Issue. 6; 2007.

 

  1. Salokhe, A. Sarkar, A. Kulkarni, S. Mukherjee and J. K. Pal, Flufenoxuron, an acylura insect growth regulator, alters development of Tribolium castaneum (Herbst) (coleoptera: tenebrionidae) by moulding levels of chitin, soluble protein content, and HSP70 and p34cdc2 in the larval tissue. Pesticide Biochem & Physiology, Vol. 85, 84-90, 2006.

 

  1. Sarkar, A. Kulkarni, S. Chattopadhyay, D. Mogare, K. K. Sharma, K. Singh, J. K. Pal, Lead-induced upregulation of the heme-regulated eukaryotic initiation factor 2α kinase is compromised by hemin in human K562 cells. BBA-Gene structure and expression, 1732, 15-22, 2005.

 

  1. Sarkar, S. Chattopadhyay, R. Kaul and J. K. Pal, Lead exposure and heat shock inhibit cell proliferation in human HeLa and K562 cells by inducing expression and activity of the heme-regulated eIF-2α kinase. Journal of Biochemistry, Molecular biology and Biophysics, Vol. 6 (6), 391-396, December 2002.

 

  1. K. Pal., A. Sarkar., and B. Katoch, Detergent mediated destaining of Coomassie Brilliant Blue –stained SDS polyacrylamide gels. Indian Journal of Experimental Biology, Vol. 39, January 2001, 95-97, 2001.

 

Book chapter:

 

  • Dibakar Chakrabarty and Angshuman Sarkar, Cytotoxic Effects of Snake Venoms, Springer Science, Business Media Dordrecht Gopalakrishnakone et al. (eds.), Snake Venoms Toxinology, 2016, DOI 10.1007/978-94-007-6648-8_34-1.

 

Conference Proceedings:

 

1) A. Sarkar, J. K. Pal, "Inhibition of protein synthesis during lead poisoning is mediated by the heme-regulated eIF-2 alpha kinase" All India Cell Biology Conference, Pg: 198, New Delhi, India, 2000.

 

2) J. K. Pal, A. Sarkar and S. Anand, "The heme-regulated eIF-2 alpha kinase, a regulator of protein synthesis, as a potential molecular indicator forAnemia and lead toxicity and heat- shock". Society of Biological Chemist, Calcutta, India, 2000.

 

3) A. Sarkar, R. Kaul, S. Chattopadhyay and J. K. Pal, "Heavy metal exposure and heat-shock induce over expression of the heme-regulated eIF-2α kinase in human cells cultured in vitro". All India Cell Biology Conference, Bangalore, India, 2002.

 

4) A. Sarkar, J. K. Pal and S. Chattopadhyay, "Cloning of human heme-regulated eIF-2α kinase (HRI) promoter and study of its activity under various cytoplasmic stresses". All India Cell Biology Conference and International Symposium, Pune, India, 2004.

 

5) A. Sarkar, Reza N, Kar A and J. K. Pal,  "Validity of a RT-PCR based method in Diagnosis and prognosis of anemia in humans using HRI as amolecular marker". All India Cell Biology Conference and International Symposium, Pune, India, 2004.

 

6) S. Salonkhe, A. Sarkar, S. Mukherjee and J. K. Pal, "Influence of sub-lethal concentrations of an insect growth regulator flufenoxuron (Cascade R) on certain biological and molecular phenotypes in Tribolium castaneum (Herbst)" All India Cell Biology Conference and International Symposium, Pune, India, 2004.

 

7) Cordula Schulz, Angshuman Sarkar, Nishita Parikh, Stephen Hearn. Opposing roles of the EGFR and Rho-type small monomeric GTPases during niche formation. Genetics Society of America, Houston, Texas, USA, 2006. Pg 89/web.

 

8) A. Sarkar, Y. Chang and C. Schulz; “NUP98/96- key to germ line stem cell .microenvironment”. Genetics Society of America, Houston, Texas, USA, 2006. Pg 141B/web .

 

9) A. Sarkar and D. McDonald; Tracking of live HIV in human lymphoid organ, NIH, HIV and AIDS Symposium, NIH, Bethesda, USA, 2008, Pg 195C/web.

 

10) Angshuman Sarkar, J DeVecchio, T S. Jani, R Humphreys, J A. Houghton. Characterization of the differential sensitivity to rhTRAIL and to Lexatumumab in human colon carcinoma cell lines (cc). Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract No 5136.

 

11) Mohammad Azhar Aziz, J DeVecchio, T S. Jani, K L. Peters, T Mazumdar, A Sarkar, J A. Houghton. Microarray analysis of the expression levels of molecular components of relevant signaling pathways in response to FUra/IFN-gamma treatment protocols in human colon carcinoma cell lines. In: Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009.

 

12) V. V. Krishnamurthy, M. Malpe and A. Sarkar,Cadmium Toxicity triggers morphological transition in in Vitro cultured human neuroblastoma cells. AMTOX Conference, Kolkata, India 2010.

 

13) A. Rastogi, S. Biswas, A. Sarkar and D. Chakrabarty, Anticoagulant activity of moon jellyfish tentacle extract. World Congress Biotechnology, Hyderabad, 2011.

14) G. Ravindran, D. Chakrabarty and A. Sarkar. Cadmium toxicity induces morphological alteration in in vitro cultured human lung (A549) cell line, Seminar on advances in Zoology, Goa, 2012.

 

15) G. Ravindran and A. Sarkar, Cadmium Toxicity causes morphological Changes, production of stress granules and upregulation of HSP70 in human A549 cells cultured in vitro. 36th All India Cell Biology Conference, Mumbai, Pg: 163, 2012.

 

17) Sarkar A, Cell Morphology: A signaling cues for silver nanomaterial and cadmium stress. 36th AICBR & SARGI, BARC, Mumbai, 2012.

.

18) Martin A, Santimano C, Kowshik M and Sarkar. A. Zinc oxide nanoparticles cause morphological changes in human A549 cells cultured in vitro. 36th AICBR & SARGI, BARC, Mumbai, 2012, Pg 167.

 

19) Ansie Martin and Angshuman Sarkar, ZnO and TiO2 nanoparticle induces cytotoxity and morphological changes in A549 cells., Third Euro-India International Conference on Nanomedicicine and Tissue Engineering (ICNT) Kottayam, India, 2013.

 

20) Chandrasekhar, C., Anghsuman, S., Srinivas, S., Dibakar Chakrabarty. Anti-platelet activity of a three-finger toxin (3FTx) from Indian monocled cobra (Naja kaouthia) venom. 3rd Annual Conference of the Toxinological Society of India and Ist International Conference on ‘Biology of Natural Toxins’ held at BITS Pilani K K Birla Goa campus, 2013.

 

21) Jigni Sayeda Pathan, Dibakar Chakrabarty and Angshuman Sarkar. Russell’s viper venom causes alteration in cellular morphology through regulation of small GTPase in a time and dose dependent manner. TSICON, 2013 Goa.  

 

22) Geethanjali Ravindran, Snehal Nirgude, Dibakar Chakrabarty and Angshuman Sarkar. Synergistic effect of methylcobalamin on cadmium induced stress in human lung cell carcinoma (A549) cell line. TSICON 2013, Goa.

 

23) A. Sarkar, G. Ravindran and A. Martin.Heavy metal and nanoparticle induced modulation of the cell cytoskeleton through regulation of smallGTPases – emerging interrelations. EMBO Cell Cytoskeleton Workshop, Israel, Oct 2014.

 

24) Jigni, S.P., Ansie, Martin. Dibakar Chakrabarty and Angshuman Sarkar. Cytotoxic Effect of Russell’s viper Venom (RVV) in Human Alveolar Adenocarcinoma Cells (A549) Cultured in vitro. 22nd Meeting of the Societé Fracaises en Etudes de Toxines (SFET) “Toxins: New Targets and New Functions” held at Pasteur institute Paris, France, 2014.

 

25) Ansie Martin and Angshuman Sarkar, Cellular response of in vitro cultured Human A549 cells to exposure of Metal oxide nanoparticles. 38th AICB Conference and International symposium on cellular response to Drug. December 10-12, 2014.

 

26) J S Pathan, A Martin, D Chakrabarty and A Sarkar, Cytotoxic Effect of Russell’s Viper Venom (RVV) in Human Alveolar Adenocarcinoma Cells (A549) Cultured in vitro, 22nd SFET Meeting, Paris, France, 10-11December 2014.

 

27) Ansie Martin and Angshuman Sarkar, "Evaluation of metal nano-oxide stress in building a Nano QSAR model for prediction of toxicity", 23rd International Conferenceon Current Trends in Computational Chemistry (CCTCC) JACKSON; USA 2015.

 

28) A Martin, S Hazra, N N Ghosh and A Sarkar, Development of a QSAR model to predict metal nano-oxide toxicity on alveolar cells, 1st International Conference on Trends in Cell and Molecular Biology (TCMB) 2015, Goa.

 

29) G Ravindran, D Chakrabarty and A Sarkar, Cadmium induced cytotoxicity: a cell specific stress response? 1st International Conference on Trends in Cell and Molecular Biology (TCMB) 2015, Goa.

 

30) J. Pathan, A. Martin, D. Chakrabarty and A. Sarkar, Regulation of small gtpases and nuclear damage caused by  russell’s viper venom (rvv), 1st International Conference on Trends in Cell and Molecular Biology (TCMB) 2015, Goa.

 

31) M. Kumar, A. Martin and A. Sarkar, Quinacrine (QC) affects morphological changes through regulation of smallGTPase in in vitro cultured human non-small cell lung cancer (NSCLC) cell lines. International symposium on Functional Genomics and Epigenetics and all India cell biology conference, Nov. 2016, Gwalior.

32) A. Samanta, G. Ravindran and A. Sarkar, Differential effects of a small molecule ‘Qunacrine’ (QC) on human breast (MCF7) and colorectal (HCT116) cancer cell lines cultured in vitro. NRSM-2016 ACTREC, Tata Memorial Centre, Dec, 2016, Mumbai.

 

33) Makhan Kumar, Ansie Martin, Snehal Nirgude, Bibha Chaudhary and Angshuman Sarkar; Quinacrine (QC) modulates cell-cytoskeleton through regulation of small GTPases and mitochondrial apoptosis driven by stress kinases in human non-small cell lung cancer cell lines.  P376– 20180586-S.  International Federation of Cell Biology Conference, Hyderabad, 27-31st January 2018.

 

34) Angela Samanta and Angshuman Sarkar; Human colon cancer cell line HCT116 is more susceptible to anti-cancer small molecule Qunacrine (QC) as compared to INT407.   P 367– 20180588-S.  International Federation of Cell Biology Conference, Hyderabad, 27-31st January 2018.

 

35) Angshuman Sarkar, Effects of nanoparticles on human lung alveolar cells, Seminar on ‘Trends in Bio prospect Management and Nanobiotechnology’, Page 3-4, Nagpur University, Nagpur Invited talk. 25th October 2018.

 

36) Angela Samanta and Angshuman Sarkar; Anticancer effect of Quinacrine on human colorectal cancer through alteration of cell cytoskeleton and modulation of Hsp70 pertaining to apoptosis, XLII All India Cell Biology Conference and 2nd International conference, Goa, TCMB, Page 143, December 21-23, 2018.

 

37) Makhan Kumar, Snehal Nirgude, Bibha Chaudhary and Angshuman Sarkar; Quinacrine (QC) inhibits cell migration by ROS mediated activation of stress and induces apoptosis through mitochondrial pathways in non-small cell lung cancer cell lines cultured in vitro. XLII All India Cell Biology Conference and 2nd International conference on, Goa, TCMB, Page 143-144, December 21-23, 2018.

 

38) Makhan Kumar and Angshuman Sarkar; Quinacrine a 9-amino acridine small molecule induces ROS mediated activation of stress and apoptotic pathway in human non-small cell lung cancer cell lines cultured in vitro. ICIRTLS-2020, International E conference, Akola, India from 3-5th December 2020.

 

39) Angela Samanta and Angshuman Sarkar; ‘Old wine in new bottle’: exploring the potency of anti-malarial drug for treating breast cancer!” Invited talk for ‘National Seminars on Life & Life Processes: Interdisciplinary Approach for Sustainable Development, Department of Zoology, Goa University, 19-21st July 2021.