Design and synthesis of gene-targeting compounds as new and novel anticancer agents, Multi-disciplinary research programmes including organic synthesis, and their targeted delivery as prodrugs, combinatorial and green chemistry including chemical biology and biocatalysis, medicinal
Birla Institute of Technology & Science, Pilani Hyderabad Campus Jawahar Nagar, Kapra Mandal Dist.-Medchal-500 078 Telangana, India
Published over 570 research papers in reputed international journals.
Publications received more than 17,300 citations; h-index 60.
Published 34 review articles and contributed 10 chapters in books.
Total number of patents 432 (Granted 306 and Filed 126).
Five (5) of the US patents have been licensed to a pharmaceutical company for their clinical development at an upfront payment of Rs. 5 million and milestone payments of about Rs. 24 million apart from royalties on the sales.
Provided Human Resource Development and over 110 students have obtained their D. degrees under the guidance.
Delivered over 150 invited lectures at different international/national meets and seminars.
A large number of NCE’s and ICE’s have been developed, and some new lead compounds (4 to 5) are undergoing detailed biological studies for their development as potential anticancer agents.
Played a keyrole in the conceptualization and establishment of Biotechnology Incubation Centre (BTIC) at Biotech Park, Genome Valley, Hyderabad, being operated by Alexandria.
Created and established Pre-Biotechnology Process Generator facility at the Indian Institute of Chemical Technology (IICT) and also was involved in the facility creation for the Chemical Biology.
Organized many National and International conferences like Indo-German Symposium in September 1996, National Symposium in Chemistry in January 2000, 12th CRSI National Symposium in February 2010 and Royal Society of Chemistry, London MedChem Congress 2011 and 2013.
As the Project Director of NIPER, Hyderabad for about seven years, played an important role in the establishment and functioning of this National Institute.
A National Centre for Research and Development in Bulk Drugs (NCRDBD) has been conceptualized and obtained necessary approvals to setup at NIPER Hyderabad campus with a project cost of Rs. 90 crores. This will be an innovative R&D provider in the field of bulk drugs and offer competitive and eco-friendly technologies in specified areas products and processes.
Member of the Editorial Advisory Board for the journals like ChemMedChem (Wiley), Chem.Com. (RSC), J. Saudi Chem. Soc. (Elsevier) and Letters in Drug Design & Discovery (Bentham).
Expertise has attracted prestigious international projects from Yamanouchi Pharmaceutical Co. Ltd., Japan, Mitsubishi Chemical Corporation, Japan, Shiratori Pharmaceutical Co., Japan, Dupont, USA, IndUS Pharmaceuticals, USA, apart from international academic collaborations with Imperial College London, Kings College London, Greifswald University, University of Cape Town, King Saud University and University of Michigan.
Expertise has attracted prestigious international projects from Yamanouchi Pharmaceutical Co. Ltd., Japan, Mitsubishi Chemical Corporation, Japan, Shiratori Pharmaceutical Co., Japan, Dupont, USA, IndUS Pharmaceuticals, USA, apart from international academic collaborations with University of Portsmouth UK, Imperial College London, Kings College London, Greifswald University Germany, University of Cape Town South Africa, King Saud University, University of Michigan, University of the Witwatersrand, Johannesburg, South Africa, Lomonosov Moscow State University, Russia