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Prof. Ahmed Kamal 

Sr. Professor Emeritus,
Department of Pharmacy

Design and synthesis of gene-targeting compounds as new and novel anticancer agents, Multi-disciplinary research programmes including organic synthesis, and their targeted delivery as prodrugs, combinatorial and green chemistry including chemical biology and biocatalysis, medicinal
Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India

Recent Publications

  1. An update on the development on tubulin inhibitors for the treatment of solid tumors. Yakkala, P.A.; Rahaman, S.; Soukya, P.S.L.; Begum, S.A.; Kamal, A. Expert Opinion on Therapeutic Targets 2024, 28, 193-220 (Invited Review).
  2. Oxindoline containing thiazolidine-4-one tethered triazoles act as antimitotic agents by targeting microtubule dynamics. Shahjahan, S.; Naraharisetti, L.T.; Begum, A.; Yakkala, P.A.; Soukya, P.S.L.; Godugu, C.; Begum, S.A.; Kamal, A. ChemistrySelect 2024, 9, e202400539
  3. PI3K and Tankyrase Inhibitors as Therapeutic Targets in Colorectal Cancer. Yakkala, P.A.; Naaz, F.; Shafi, S.; Kamal, A. Expert Opinion on Therapeutic Targets 2024, 28, 159-177 (Invited Review).
  4. Converging thiolactone and quinoline scaffolds: New potential antitubercular conjugates. Azeeza, S.; Malik, M.S.; Alsimaree, A.A.; Khan, I.A.; Abdullah, S.T.; Jamal, Q.M.S.; Alzahrani, A.Y.A.; Moussa Z.; Asghar, B.H.; Ahmed, S.A.; Kamal, A. J. Mol. Structures 2024, 1300, 137255.
  5. Prospects of Topoisomerase Inhibitors as Promising Anti-Cancer Agents. Yakkala, P.A.; Penumallu, N.R.; Shafi, S.; Kamal, A. Pharmaceuticals, 2023, 16, 1456 (Invited Review).
  6. Multicomponent Domino Reaction for Concise Access to 2‑Amino-Substituted 1,3,4-Oxadiazoles via Smiles Rearrangement. Yakkala, P.A.; Khan, I.A.; Dannarm, S.R.; Aboti, J.; Sonti, R.; Shafi, S.; Kamal, A. J. Org. Chem. 2023, 88, 12216.
  7. Synthesis, biological evaluation and mechanistic studies of 4-(1,3-thiazol-2-yl)morpholine-benzimidazole hybrids as a new structural class of antimicrobials. Aaghaz, S.; Chander S. Digwal, C.S.; Naziya Neshat, N.; Indresh K. Maurya,
    I.K.; Vinod Kumar, V.; Kulbhushan Tikoo, K.; Jain, R.; Kamal, A. Bioorg. Chem. 2023, 136, 106538.
  8. What are the challenges involved in the strategies for future antibody-drug conjugate discovery and development for oncology? Begum, S.A..; Kamal, A., Expert Opinion on Drug Discovery, 2023, 18, 591 (Invited Review).
  9. Benzimidazole‑linked pyrazolo[1,5‑a]pyrimidine conjugates: synthesis and detail evaluation as potential anticancer agents. Bagul, C.; Rao, G.K.; Veena, I.; Kulkarni, R.; Tamboli, J.R.; Akunuri, R.; Shaik S.P.; Bhadra M.P.; Kamal, A., Mol. Diversity 2023, 27, 1185.
  10. Antibacterial Properties and Computational Insights of Potent Novel Linezolid-Based Oxazolidinones. Malik, M.S.; Faazil, S.; Alsharif, M.A.; Jamal, Q.M.S.; Al-Fahemi, J.H.; Benerji, A.; Chattopadhyay, A.; Pal, S.K.; Kamal, A.; Ahmed, S.A., Pharmaceuticals 2023, 16, 516.
  11. Pyridine-Based 1,2,4-Triazolo-Tethered Indole Conjugates Potentially Affecting TNKS and PI3K in Colorectal Cancer. Yakkala, P.A.; Panda, S.R.; Naidu, V.G.M.; Shafi, S.; Kamal, A., ACS Med. Chem. Lett. 2023, 14, 260.
  12. New quinoline-thiolactone conjugates as potential antitubercular and antibacterial agents. Faazil, S.; Malik, M.S.; Ahmed, S.A.; Jamal, Q.M.S.; Basha, S.T.; Qurban, J.; Asghar, B. H.; Obaid, R.J.; Shaikh, I.N.; Kamal, A., J. Mol. Structures 2023, 1271, 134099.
  13. Synthesis and cytotoxic activity of 1,2,4-triazolo-linked bis-indolyl conjugates as dual inhibitors of tankyrase and PI3K. Yakkala, P.A.; Panda, S.R.; Shafi, S.; Naidu, V.G.M.; Shahar Yar, M.; Ubanako, P.N.; Adeyemi, S.A.; Kumar, P.; Choonara, Y.E.; Radchenko, E.V.; Palyulin, V.A.; Kamal, A., Molecules 2022, 27, 7642.
  14. COVID-19: vaccines and therapeutics, Ponnampalli, S.; Birudukota, N.V.S.; Kamal, A., Bioorg. Med. Chem. Lett. 2022, 75, 128987.
  15. Novel linezolid-based oxazolidinones as potent anticandidiasis and antitubercular agents Faazil, S.; Malik, M.S.; Ahmed, S.A.; Alsantali, R.I.; Yedla, P.; Alsharif, M.A.; Shaikh, I.N.; Kamal, A., Bioorg. Chem. 2022, 126, 105869.
  16. Novel approaches to the development of direct KRAS inhibitors: Structural insight and drug design. Sharma, A.; Yakkala, P.A.; Yar, M.S.; Shafi, S.; Kamal, A., Expert Opinion on Drug Discovery, 2022, 17, 247 (Invited Review).
  17. Synthesis and characterization of novel combretastatin analogues of 1,1 diaryl vinyl sulfones, with antiproliferative potential via in silico and in vitro studies. Egharevba, G.; Kamal, A.; Dosumu, O.; Routhu S.; Fadare O.; Oguntoye S.; Njinga S.; Oluyori, A., Scientific Reports., 2022, 12, 1901.