Publications 

62

 Manisha Malani, Mansi Shah, Thirumurthy Velpandian, Jayabalan Nirmal, Organic cation transporter 1 in the lacrimal gland facilitates the entry of systemic drugs causing ocular surface toxicity. Experimental Eye Research, 2024, Impact factor - 3

61

Vaidehi Garg, Jayabalan Nirmal, Musarrat Husain Warsi, Nazeer Hasan, Gaurav K. Jain,Efflux transporter inhibitory (EXTRIN) micelles for enhanced ocular drug delivery,Journal of Drug Delivery Science and Technology,Volume 100,2024,106020,ISSN 1773-2247,Impact factor 4.5.

60

Shameer Ahmed B, Gunjan Baijal, Rudrappa Somashekar, Ridahunlang Nongkhlaw, Jayabalan Nirmal, Vijayashree Nayak, Improving chemoradiotherapy strategy with PEGylated doxorubicin loaded gold nanoparticles against oral cancers, Radiation Physics and Chemistry, June 2024,Impact factor:2.9.

59

Dhanwini Rudraprasad, Velmurugan K, Jayabalan Nirmal,Mohammed Ali, and Joveeta Joseph Ruben, Extracellular vesicle-associated Complement cascade 8 - alpha and Calpain-2 in Human vitreous as biomarkers of Infectious Endophthalmitis,Translational Vision Science & Technology (TVST), May 2024,Impact factor:3.2.

58

Aman Khandelwal,K Gowthamarajan,Jayabalan Nirmal, S Ponnusankar ,Exploring the Therapeutic Potentialof Anti-VEGF Drugs for the Management of Diabetic Retinopathy:An Overview.Curr Diabetes Rev.2024 Apr 16,Epub ahead of print,PMID:38629377,Impact Factor: 3.3.

57

Priyadarshini Sathe, Velmurugan Kailasam, Vasagiri Nagarjuna, Hanuman Sharma, Thirumurthy Velpandian, Prashant Garg, Jayabalan Nirmal*, Nanomicelles empower natamycin in treating fungal keratitis: An in vitro, ex vivo and in vivo study,International Journal of Pharmaceutics,2024,Impact Factor 5.8.

56

K. Velmurugan, B.N. Kumara, K.Sudhakara Prasad*, Jaybalan Nirmal*. Combination of self-assembling system and N,O-carboxymethyl chitosan improves ocular residence of anti-glaucoma drug. European Journal of Pharmaceutics and Biopharmaceutics. 2024. Impact Factor 4.9.  

55 

B.N. Kumara, K. Velmurugan, M. Vivek Ghate, R. Shambhu, Jayabalan Nirmal*, K. Sudhakara Prasad*. A Promising ‘Single’ and ‘Dual’ Drug-Nanocomposite Enriched Contact Lens for the Management of Glaucoma in Response to Tear Fluid Enzyme.  Journal of Materials Chemistry B, 2024.Impact Factor 7.5.

54

Manisha Malani, Aiswarya Thattaru Thodikayil, Sampa Saha, Jayabalan Nirmal*, Carboxylated nanofibrillated cellulose empowers moxifloxacin to overcome Staphylococcus aureus biofilm in bacterial keratitis, Carbohydrate polymers, 2023. Impact Factor 11.2.

53

Sakshi Priya, Gorantla Srividya, Nittala Sarath Chandra, Prem Prakash Singh, Ranendra N. Saha, Priyadarshini Sathe, Jayabalan Nirmal, Gautam Singhvi Loteprednol etabonate loaded lyotropic liquid crystalline nanoparticles in-situ ophthalmic gel: Qbd driven optimization and in-vitro, ex-vivo evidence of sustained precorneal residence time, Journal of Drug Delivery Science and Technology, 2023.Impact Factor 5. 

52 

B.N Kumara, R. Shambhu,  Yoon-Bo Shim, Jayabalan Nirmal, K.Sudhakara Prasad, Development of mucoadhesive Timolol loaded chitosan-nanocomposite to treat glaucoma, International Jouranl of Biological Macromolecules, 2023. Impact Factor 8.2. 

51

Manisha Malani, Manthan S. Hiremath, Surbhi Sharma, Manisha Jhunjhunwala, Shovanlal Gayen, Chittaranjan Hota* & Jayabalan Nirmal* , Interaction of systemic drugs causing ocular toxicity with organic cation transporter: an artificial intelligence prediction, Journal of Biomolecular Structure and Dynamics,2023. Impact Factor 5.23.

50

Madhusudan B. Kulkarni, K Velmurugan, Jayabalan Nirmal*, Sanket Goel*, Development of Dexamethasone loaded Nanomicelles using a 3D Printed Microfluidic Device for Ocular Drug Delivery Applications. Sensors and Actuators A : Physical,2023. Impact Factor 4.29.

49  

Velmurugan Kailasam, Sai Shreya Cheruvu, Manisha Malani, Srujana Mosalikanti Sai Kameshwari, Prashant Kesharwani, Jayabalan Nirmal*. Recent advances in novel formulation approaches for tacrolimus delivery in treatment of various ocular diseases. Journal of Drug Delivery Science and Technology, 2022. Impact Factor 5.06. 

48   

Malani, M., Nirmal J. Retinal Pathophysiological Evaluation in a Rat Model. J. Vis. Exp.(183), e63111,  2022. Impact Factor 1.355. 

47

Gaurav R. Pandey, Pandiyaraj Kanagavalli, Kalyani Karnam, K. Thanigai Arul, Periyasamy Monisha, Chung-Li Dong, Jeng-Lung Chen, Murugan Veerapandian*, Jayabalan Nirmal*. Molybdenum Trioxide Hybridized Kaempferol: A Double-Powered Nanosystem for Salvaging Oxidative Stress and Electrochemical Immunoprobing of Interleukin-6. Materials Today Chemistry, 2022. Impact Factor 8.01. 

46

Deepika Modi, Jayabalan Nirmal, Meenakshi Bhatia, Prashant Kesharwani, Gaurav K. Jain. Formulation and development of tacrolimus-gellan gum nanoformulation for treatment of dry eye disease, Colloids and Surfaces B: Biointerfaces, 2021. Impact factor 5.268

45

Mohammad, Vaidehi Garg, Jayabalan Nirmal, Musarrat H. Warsi, Deepti Pandita, Prashant Kesharwani, Gaurav Kumar Jain. Topical tacrolimus progylcosomes nano-vesicles as a potential therapy for experimental dry eye syndrome. Journal of Pharmaceutical Sciences, 2021, Sep 29;S0022-3549(21)00525-6, PMID: 34599998 Impact factor 3.534

44

Manisha Malani, Prerana Salunke, Shraddha Kulkarni, Gaurav K Jain, Afsana, Prashant Kesharwani, Jayabalan Nirmal*. Repurposing pharmaceutical excipients as an antiviral agent against SARS-CoV-2, J Biomater Sci Polym Ed, 2021 Aug 31;1-27, 2021. Impact factor  3.517

43

Madhusudan B Kulkarni, Velmurugan K, Prasanth K Enaganti, Khairunnisa Amreen, Jayabalan Nirmal, and Sanket Goel. Smartphone Enabled Miniaturized and Automated Temperature Controller Platform to Synthesize NiO/CuO and Nanomicelles for Electrochemical Sensing and Ocular Drug Delivery Applications. Biomedical Microdevices, 2021, 6;23(2):31 (1-13), PMID: 34091727. Impact factor 2.838

42

Thirumurthy Velpandian, Jayabalan Nirmal, Hanuman Prasad Sharma, Sanjay Sharma, Namrata Sharma, Nabanita Halder. Novel Water Soluble Sterile Natamycin Formulation (Natasol*) for Fungal Keratitis. European Journal of Pharmaceutical Sciences, 2021, 163:105857, PMID: 33882328  Impact factor 4.384

41

Vaidehi Garg, Gaurav Kumar Jain, Jayabalan Nirmal, Yassine Riadi, Prashant Kesharwani, Kanchan Kohli. Amelioration of endotoxin-induced uveitis in rabbit by topical administration of tacrolimus proglycosome nano-vesicles. Journal of Pharmaceutical Sciences, November 2020. Impact factor 3.534

40

Sudeep Kumar Gadea, Jayabalan Nirmal, Prashant Garg, Venkata Vamsi Krishna Venuganti. Corneal delivery of moxifloxacin and dexamethasone combination using drug-eluting mucoadhesive contact lens to treat ocular infections. Int J Pharmaceutics, 591, 120023, 2020,  Impact factor 5.875

39

Gaurav Kumar Jain, Jayabalan Nirmal, Geeta Aggarwal, Harvinder Popli. Bioscintigraphy: A Branding Opportunity For Drug Products. Pharma Times, 52 (8), 2020, 27

38

Jayabalan Nirmal*, Veluchamy A. Barathi, Andreas Dickescheid, Yeo Sia Wey, Sonali Nirmal, Miguel Moreno Raja, Subbu Venkatraman, Rupesh Agrawal. Potential of subconjunctival aflibercept in treating choroidal neovascularization. Exp Eye Res, 2020 Aug 12;199:108187. doi: 10.1016/j.exer.2020.108187.  Impact factor 3.467 *Corresponding author

37

Rohit Bisht, Sonali Nirmal, Rupesh Agrawal, Gaurav K Jain, Jayabalan Nirmal*. Injectable in-situ gel depot system for targeted delivery of biologics to the retina. Journal of Drug Targeting, 2020. *Corresponding author Impact factor 5.121

36

Anurag T. K. Baidya,  Kalyan Ghosh,  Sk. Abdul Amin, Nilanjan Adhikari, Jayabalan Nirmal,*   Tarun Jha*, Shovanlal Gayen*. In silico modelling, identification of crucial molecular fingerprints, and prediction of new possible substrates of human organic cationic transporters 1 and 2. New J. Chem., 2020,44, 4129-4143. * Corresponding author Impact factor  3.591

35

Moreno M, Pow PY, Tabitha TST, Nirmal S, Larsson A, Radhakrishnan K, Nirmal J, Quah ST, Geifman Shochat S, Agrawal R, Venkatraman S. 2017, Modulating release of ranibizumab and aflibercept from thiolated chitosan-based hydrogels for potential treatment of ocular neovascularization. Expert Opin Drug Deliv, 14(8), 913-925. PMID: 28643528 Impact factor 6.648

34

Radhakrishnan K, Sonali N, Moreno M, Nirmal J, Fernandez AA, Agrawal R, Venkatraman S. 2017, Protein delivery to the back of the eye: barriers, carriers and stability of anti-VEGF proteins. Drug Discovery Today, 22(2), 416-423. PMID: 27818255 Impact factor 7.851

33

Killinger K, McLennan G, Nirmal  J, Chancellor MB, Peters K. 2017, Urine chemokine levels correlate with treatment response to pde4 inhibitor in prostatitis, World Journal of Clinical Urology, 6(1): 18-26 Impact factor 4.226

32

Nirmal J*, Radhakrishnan K, Moreno M, Natarajan JV, Laude A, Lim TH, Venkatraman S, Agrawal R. 2016, Drug, delivery and devices for diabetic retinopathy (3Ds in DR). Expert Opin Drug Deliv. 30:1-13. PMID: 27169870 * Corresponding author Impact factor 6.648

31

Tan HY, Agarwal A, Lee CS, Chablani J, Gupta V, Nirmal J, Pavesio C, Agrawal R. 2016, Management of noninfectious posterior uveitis with intravitreal drug therapy, Clinical Ophthalmology, 10, 1983-2020. PMID: 27789936,  Impact factor 2.14

30

Ho DCW, Agarwal A, Lee CS, Chhablani J, Gupta V, Khatri M, Nirmal J, Pavesio C, Agrawal R. 2016, Review of the role of intravitreal corticosteroids as an adjuvant to antibiotics in Infectious Endophthalmitis, Ocular Immunology and Inflammation, Nov 16, 1-8. PMID: 27849402 Impact factor 3.070

29

Moreno MR, Tabitha TST, Nirmal J, Radhakrishna K, Chua HY, Lim S, Subbu Venkatraman S, Agrawal R. 2016, Study of stability and biophysical characterization of ranibizumab and Aflibercept, Eur J Pharm & Biopharm, 108, 156-167. PMID: 27615995 Impact factor 5.571

28

Kee AR, Gonzaelz-Lopez JJ, Al-Hity A, Gupta B, Lee CS, Gunasekeran DV, Nirmal J, Grant R, Kon OM, Gupta V, Westcott M, Pavesio CE, Agrawal R. 2016, Anti-tubercular therapy for intraocular tuberculosis: Systematic review and meta-analysis. Surv Ophthalmol, 61(5), 628-53. PMID: 26970263,  Impact factor 4.75

27

Rajaganapathy BR, Chancellor MB, Nirmal J, Dang L, Tyagi P. 2015, Bladder uptake of liposomes after intravesical administration occurs by endocytosis. PLoS One, 10(3), e0122766. Impact factor 3.240

26

Peters KM, Jayabalan N, Don B, Kim K, Chancellor M, Tyagi P. 2015, Effect of Sacral Neuromodulation on Outcome Measures and Urine Chemokines in Interstitial Cystitis/Painful Bladder Syndrome Patients. Lower urinary tract symptoms, 7, 77–83. PMID: 26663686 Impact factor 1.592

25

S Gayen, N Jayabalan, S Basak. Nuclear Magnetic Resonance (NMR) Spectroscopy in Protein Research. 2015, Journal of Pharma Sci Tech, Volume 4, Issue 2,  Impact factor  3.246

24

Nirmal J, Chuang YC, Lee W, Yoshimura N, Huang C, Tyagi P, Raja RB, Chancellor MB. 2014, Functional and Molecular Characterization of Hyposensitive Underactive Bladder tissue and urine in Streptozotocin-Induced Diabetic Rat. PLoS One, 22;9(7):e102644. PMID: 25050870 Impact factor 3.240

23

Nirmal J, Wolf-Johnston A, Chancellor MB, Tyagi P, Anthony M, Kaufman J, Birder LA. 2014, Liposomal inhibition of acrolein-induced injury in rat cultured urothelial cells. Int Urol Nephrol. 46(10):1947-52 PMID: 24875005 Impact factor  2.370

22

Garg V, Jain GK, Nirmal J, Warsi MH, Ahmad FJ, Khar RK. 2014, Development of Poly Lactide-Co-Glycolide Nanodispersions for Enhanced Ocular Delivery of moxifloxacin. Science of Advanced Materials, 6(5), 990-999 Impact factor 1.474

21

Arora B, Angayarkanni N, Nirmal J, Halder N, Patnaik S, Ravi AK, Velpandian T. 2014, Development and validation of a LC-MS/MS method for homocysteine thiolactone in plasma and evaluation of its stability in plasma samples. J Chromatography B, 944:49-54. PMID: 24291720,  Impact factor 3.205

20

Rajaganapathy BR, Jayabalan N, Tyagi P, Kaufman J, Chancellor MB. 2014, Advances in Therapeutic Development for Radiation Cystitis. Lower urinary tract symptoms, 6:1-10. PMID: 26663493,  Impact factor 1.5

19

Nirmal J, Sirohiwal A, Singh SB, Biswas NR, Thavaraj V, Azad RV, Velpandian T. 2013, Role of organic cation transporters in the ocular disposition of its intravenously injected substrate in rabbits: implications for ocular drug therapy. Exp Eye Res, 24;116C:27-35. PMID: 23892056 Impact factor 3.467

18

Nirmal J, Velpandian T, Singh SB, Biswas NR, Thavaraj V, Azad RV. 2013, Potential Pharmacokinetic Role of Organic Cation Transporters in Modulating the Transcorneal Penetration of its Substrates Administered Topically. Eye, 27(10):1196-203. PMID: 23846373,  Impact factor 3.77

17

Nirmal J, Tyagi P, Chancellor MB, Kaufman J, Anthony M, Chancellor DD, Chen YT, Chuang YC. 2013, Development of Potential Orphan Drug Therapy of Intravesical Liposomal Tacrolimus for Hemorrhagic Cystitis Due to Increased Local Drug Exposure. J Urol, 189(4):1553-8. PMID: 23127767 Impact factor  7.450

16

Garg V, Jain GK, Nirmal J, Kohli K. 2013, Topical tacrolimus nanoemulsion, a promising therapeutic approach for uveitis. Med Hypotheses. 81(5):901-4. PMID: 24018283 Impact factor 1.538

15

Nirmal J, Velpandian T, Singh SB, Biswas NR, Azad R, Thavaraj V, Mittal G, Bhatnagar A, Ghose S. 2012, Evaluation of the functional importance of organic cation transporters on the ocular disposition of its intravitreally injected substrate in rabbits. Curr Eye Res. 37(12):1127-35. PMID: 22916711 Impact factor 2.424

14

Nirmal J, Chuang YC, Tyagi P, Chancellor MB. 2012, Intravesical Therapy for LUTS. Urological Science, 23,70-77 Impact factor 0.233

13

Tyagi P, Killinger K, McLennon G, Nirmal J, Chancellor M, Peters KM. 2012, Urine chemokines levels correlate with treatment response to phosphodiesterase 4 inhibitor in prostatitis patients. J Urol. 187(6):2243-8. PMID: 22503040 Impact factor  7.450

12

Nickel JC, Partin AW, Nirmal J, Chancellor MB, Loeb S, Brawer MK, Assimos D, Shapiro E. 2012, Best of the  2012 AUA Annual Meeting: Highlights From the 2012 American Urological Association Meeting, May 19-23, 2012, Atlanta, GA. Rev Urol. 14(3-4):90-103. PMID: 23526762,  Impact factor  14.43

11

Velpandian T, Nirmal J, Arora B, Ravi AK, Kotnala A. 2012, Understanding the Charge Issues in Mono and Di-Quaternary Ammonium Compounds for Their Determination by LC/ESI-MS/MS. Anal Letters. 45(16):2367-2376,  Impact factor  2.329

10

Satheeshkumar N, Nisha N, Sonali N, Jain GK, Nirmal J, Spandana V. 2012, Analytical Profiling of Bioactive Constituents from Herbal Products, using Metabolomics - A Review. Natural Product Communications.  7(8):1111-5. PMID: 22978242  Impact factor  0.986

9

Jain GK, Warsi MH, Nirmal J, Garg V, Pathan SA, Ahmad FJ, Khar RK. 2012, Therapeutic stratagems for vascular degenerative disorders of the posterior eye. Drug Discov Today. 17(13-14):748-59. PMID: 22504325  Impact factor  7.851

8

Nirmal J, Velpandian T, Biswas NR, Vasantha T, Azad RV, Basker S, Ghose S. 2011, Development and validation of a highly sensitive LC–MS/MS method for organic cation transporter (OCT) substrate tetraethylammonium (TEA) in rabbits. J Chromatography B, 879(9-10): 585–590. PMID: 21317050,  Impact factor 3.205

7

Brawer MK, Loeb S, Partin AW, Nirmal J, Chancellor MB, Nickel JC, Rajfer J, Shapiro E, Roehrborn CG. 2011,  Best of the AUA Annual Meeting: Highlights From the 2011 American Urological Association Meeting, May 14-19, 2011, Washington, DC. Rev Urol. 13(3):151-72. PMID: 22114546,  Impact factor  14.43

6

Jain GK, Pathan SA, Akhter S, Jayabalan N, Talegaonkar S, Khar RK, Ahmad FJ. 2011, Microscopic and spectroscopic evaluation of a novel PLGA-chitosan Nanoplexes as ocular delivery system. Colloids and Surfaces B: Biointerfaces. 82 (2): 397-403. PMID: 20940097 Impact factor 5.268

5

Kumar NS, Nisha N, Nirmal J, Sonali N and Bagyalakshmi J. 2011, HPLC Determination of Pitavastatin Calcium in Pharmaceutical Dosage Forms. Pharm Anal Acta, 2(2)  Impact factor 4.76

4

Senthilkumari S, Lalitha P, Prajna NV, Haripriya A, Nirmal J, Gupta P, Velpandian T. 2010, Single and Multidose Ocular Kinetics of extemporaneous formulation of Topical Voriconazole in Humans and its Stability. Curr Eye Res, 35(11): 953-60. PMID: 20958183 Impact factor  2.424

3

Velpandian T, Nirmal J, Gupta P, Vijayakumar A.R., Ghose S. 2010, Evaluation of Calcium Dobesilate for its Anti-Cataract Potential in Experimental Animal Models. Methods and Findings in Exp. & Clin. Pharm. 32(3): 171-179. PMID: 20448859,  Impact factor  2.37

2

Nirmal J*, Saisivam S, Peddanna CH, Muralidharan S, Godwin K, Nagarajan M. 2008, Bilayer Tablets of Atorvastatin Calcium and Nicotinic Acid: Formulation and Evaluation. Chem Pharm Bull, 56(10): 1455-1458. PMID: 18827389 * Corresponding author,  Impact factor 1.645

1

Nirmal J, Saravana Babu C, Harisudhan T, Ramanathan M. 2008, Evaluation of Behavioral and antioxidant activity of Cytisus scoparius Link in rats exposed to chronic unpredictable mild stress. BMC Complement Altern Med, 24;8(1):15. PMID: 18435835 Impact factor 3.659