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Prof. Pragya Komal

Associate Professor
Department of Biological Sciences

Ligand-gated ion channels (mainly nicotinic acetylcholine receptors) function in health and neurological disorders, Homeostatic synaptic plasticity, Vitamin D3 and Brain health, Vitamin D3 and nicotine addiction, Neuro-nanoscience
Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India

Publications

FROM BITS

  1. Manjari SKV, Sharon Mariam Abraham, Omalur Eshwari, Kishore Golla, Priya Jhelum, Shuvadeep Maity, and Pragya Komal# Tremendous fidelity of Vitamin D3 in age-related neurological disorders. (2024) Molecular Neurobiology# corresponding author; DOI: 10.1007/s12035-024-03989-w
  2. Renu Heir*, Zahra Abbasi*, Pragya Komal, Haider Altimimi, Marie Franquin, Dionysia Moschou, Julien Chambon, and David Stellwagen# Astrocytes are the source of TNF mediating homeostatic synaptic plasticity. (2024) Journal of Neuroscience (accepted).
  3. Manjari SKV, Sharon Mariam Abraham, Poornima R, Rajnish Kumar Chaturvedi, Shuvadeep Maity, Pragya Komal*; Unprecedented effect of Vitamin D3 on T-cell receptor beta subunit and alpha7 nicotinic acetylcholine receptor expression in a 3-nitropropionic acid induced mouse model of Huntington’s disease. *corresponding author; 15-116-125, (2023), IBRO Neuroscience Reportshttps://doi.org/10.1016/j.ibneur.2023.07.001
  4. Julien ChambonPragya KomalGil M. LewitusGina M. KempSimone ValadeHouaria AdaidiNoura Al Bistami , and David StellwagenEarly TNF-dependent regulation of excitatory and inhibitory synapses on striatal direct pathway medium spiny neurons in the YAC128 mouse model of Huntington’s disease; (2023), Journal of Neuroscience, https://doi.org/10.1523/JNEUROSCI.1655-22.2022.
  5. Pragya Komal*, Manjari SKV, Raad Nashmi; (Invited Review)An opinion on the debatable function of brain resident immune protein, T-cell receptor beta subunit in the central nervous system (2022)IBRO Neuroscience Reports, * corresponding author, https://doi.org/10.1016/j.ibneur.2022.09.003
  6. Manjari SKV, Shuvadeep Maity, Poornima R, Suk-Yu Yau, Vaishali K, David Stellwagen and Pragya Komal*; Restorative action of Vitamin D3 on motor dysfunction through enhancement of neurotrophins and antioxidant expression in the striatum (2022), Neuroscience, * corresponding author. https://doi.org/10.1016/j.neuroscience.2022.03.039
  7. Maity S, Komal P Impact of ER Stress and ER-Mitochondrial Crosstalk in Huntington’s Disease. , Kumar V, Saxena A, Tungekar A, Chandrasekar V (2022) International Journal of Molecular Sciences. 23(2):780.
  8.  Thomas H Lee, Ahadullah, Brian R Christie, Kangguang Lin, Parco Ming-fai Siu, Li Zhang, Tifai Yuen,  Pragya Komal, Aimin Xu, Kwok-fai So, Suk-yu Yau (2021) Chronic AdipoRon treatment mimics the effects of physical exercise on restoring hippocampal neuroplasticity in diabetic mice; Molecular Neurobiology.
  9.  Anurag Gautam, Pragya Komal, Ram Sevak Singh, Prabhat Gautam, S. K. V. Manjari, R. S. Ningthoujam (2021); Hardcore producer of polyvinyl alcohol as reducer for the formation of gold nanoparticles Journal of molecular Liquid 334 (116112).
  10.  Anurag Gautam, Pragya Komal, Prabhat Gautam, Ashutosh Sharma, Neeraj Kumar and Jae Pil Jung Recent Trends in Noble Metal Nanoparticles for Colorimetric Chemical Sensing and Micro-Electronic Packaging Applications (2021) Metals, 11(2), 329.
  11.  Anurag Gautam, Pragya Komal and Ram S. Singh, Future demands for high field MRI diagnostic Journal of chemical sciences (2019) 131 (89).
  12.  Anurag Gautam and Pragya Komal*, Probable ideal size of Ln3+-based upconversion nanoparticles for single and multimodal imaging Co-ordination Chemistry Reviews; *corresponding author; (2018) 393–404 (376).

BEFORE BITS

  1. Renda A, Penty N, Pragya Komal, Nashmi R (2016) Vulnerability to nicotine self-administration in adolescent mice correlates with age-specific expression of α4* nicotinic receptors Neurophrama, 3908(16)30160-5Impact factor- 5
  2. Pragya Komal, Nashmi R (2015) T-cell receptors modify neuronal function in the central nervous system Biochem Pharmacol97, 512–517 Impact factor - 5.009.
  3. Pragya Komal, Estakhr J, Kamran M, Renda A, Nashmi R (2015) cAMP-dependent protein kinase inhibits α7 nicotinic receptor activity in layer 1 cortical interneurons through activation of D1/D5 dopamine receptors J Physiol 593.16, 3513–3532 Impact factor -  5.182.
  4. Pragya Komal, Gudavicius G, Nelson CJ, Nashmi R (2014) T cell receptor activation decreases excitability of cortical interneurons by inhibiting α7 nicotinic receptors. J Neurosci 34(1): 22-35 (Featured article) Impact factor - 6.167.
  5. Dau A*, Pragya Komal*, Truong M, Morris G, Evans G, Nashmi R (2013) RIC-3 differentially modulates alpha4beta2 and alpha7 nicotinic receptor assembly, expression, and nicotine-induced receptor upregulation.  BMC Neurosci, 3908(16)30160-5, * denotes equal contribution by authorsImpact factor – 3.
  6. Pragya Komal, Evans G, Nashmi R (2011) Rapid agonist application system for fast activation of ligand-gated ion channels. J Neurosci Methods 198: 246-254.  Impact factor - 2.785.