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Prof. Ruchi Jain Dey

Assistant Professor
Department of Biological Sciences

Development of novel drugs, Host-pathogen interaction with respect to tuberculosis, Infection induced infertility- exploring new biomarkers and in vitro models, Novel rapid molecular diagnostics for infectious diseases, therapeutics and vaccination approaches
A-115A,
Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India

Publications

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Total Citations (As of May 19, 2023): 677; H-index: 12; i10 index: 12

 Complete list of publications

Total Citations (As of May 19, 2023): 677; H-index: 12; i10 index: 12

 

Complete list of publication

  1. Dey RJ*, Dey B, Harriff M, Canfield ET, Lewinsohn DM, Bishai WR. Augmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence. mBio. 2022 Feb 15;13(1):e0386521. doi: 10.1128/mbio.03865-21. Epub ahead of print. PMID: 35164552; PMCID: PMC8844931. (JIF:7.86). (* First and co-corresponding author)- After joining BITS
  2.  Ruchi Jain Dey, Bappaditya Dey, Alok Kumar Singh, Monali Praharaj and Bishai WR. BCG overexpressing an  endogenous STING agonist provides enhanced protection against pulmonary tuberculosis. The Journal of Infectious Diseases. 221(7). pii: jiz116. doi: 10.1093/infdis/jiz116. 1048-1056. 2020 (IF: 5.02) (First author) - After joining BITS
  3. Dey, Ruchi Jain,Dey B, Zheng Y, Cheung L, Zhou J , Sayre D, Kumar P, Guo H, Lamichhane G, Sintim HO and Bishai WR. Inhibition of innate immune cytosolic surveillance by a  tuberculosis phosphodiesterase. Nature Chemical Biology 13(2). doi:10.1038/nchembio.2254. 210-217. 2017 (IF:12.15) (First author)
  4. Bappaditya Dey, Ruchi Jain Deyet al. A bacterial cyclic dinucleotide activates the cytosolic surveillancepathway and mediates innate resistance to tuberculosis. Nature Medicine. 21 (4). doi:10.1038/nm.3813. 401-406. 2015 (IF: 53.44) (Second author)
  5. Priyanka Chauhan, Ruchi Jain, Bappaditya Dey, Anil K Tyagi. Adjunctive immunotherapy with α-crystallin based DNA vaccination reduces Tuberculosis chemotherapy period in chronically infected mice. Sci Rep 3. doi:10.1038/srep01821. 1821. 2013 (IF: 4.379) (Second author)
  6. Ruchi Jain, Bappaditya Dey, Anil K Tyagi. Response of the authors to the letter entitled, “Warning: Differences in the copy number of duplication unit 2 (DU2) within BCG Danish 1331 may influence findings involving genetically-modified BCG Danish strains” by Dr. Douglas S. Kernodle. 30 (42). 6015. 2013 (IF: 3.641) (First author)
  7. Jain R, Dey B, Tyagi AK. Development of the first oligonucleotide microarray for global gene expression profiling in guinea pigs: defining the transcription signature of infectious diseases. BMC Genomics.  doi:10.1186/1471-2164-13-520. 520. 2012 (IF: 3.969) (First author)
  8. Jain R, Dey B, Khera A, Srivastav P, Gupta UD, Katoch VM, Ramanathan VD, Tyagi Over-expression of superoxide dismutase obliterates the protective effect of BCG against tuberculosis by modulating innate and adaptive immune responses. Vaccine. 29(45). 8118-25. 2011(IF: 3.641) (First author)
  9. Dey B, Jain R, Gupta UD, Katoch VM, Ramanathan VD, Tyagi AK. A booster vaccineexpressing a latency-associated antigen augments BCG induced immunity and confers enhanced protection against tuberculosis. PLoS One. 6(8) doi: 10.1371/journal.pone.0023360. e23360. 2011 (IF: 3.24) (Co-first author)
  10. Dey B, Jain R, Khera A, Gupta UD, Katoch VM, Ramanathan VD, Tyagi AK. Latency antigen α-crystallin based vaccination imparts a robust protection against TB by modulating the dynamics of pulmonary cytokines. PLoS One. 18;6(4). doi: 10.1371/journal.pone.0018773. e18773. 2011(IF: 3.24) (Co-first author)
  11. Dey B, Jain R, Khera A, Rao V, Dhar N, Gupta UD, Katoch VM, Ramanathan VD, Tyagi AK. Boosting with a DNA vaccine expressing ESAT-6 (DNAE6) obliterates the protection imparted by recombinant BCG (rBCGE6) against aerosol Mycobacteriumtuberculosis infection in guinea pigs.  10;28(1). doi: 10.1016/j.vaccine.2009.09.121. 63-70. 2009 (IF: 3.641) (Co-first author)
  12. Jain R, Dey B, Dhar N, Rao V, Singh R, Gupta UD, Katoch VM, Ramanathan VD, Tyagi AK. Enhanced and enduring protection against tuberculosis by recombinant BCG-Ag85C and its association with modulation of cytokine profile in lung. Epub 2008. PLoS One.3(12) doi: 10.1371/journal.pone.0003869. e3869. 2008 (IF: 3.24) (First author)
  13. Vivek Rao, Neeraj Dhar, H. Shakila, Ramandeep Singh, Aparna Khera, Ruchi Jainet al. Over-expression of the 19kDa lipoprotein of Mycobacterium tuberculosis obliterates the protective efficacy of BCG by polarizing the host immune responses to the Th2 phenotype.  J. Immunol. 61(5) 410-17. 2005 (IF: 3.487) (Co-author)

Book chapters:

 

1.    Naresh Patnaik, Neha R Ashtikar, Ruchi Jain DeySocial networking between microbial frenemies: Therapeutic potential of targeting polymicrobial interactions within biofilms. In: Sabu Thomas and Divya M. Prabhakaran, Emerging Concepts in Bacterial Biofilms: Molecular Mechanisms and Control Strategies. 2019. Cambridge Scholars Publishing Ltd, England, UK (* Corresponding author) 

2.    Ruchi Jain, Bappaditya Dey and Anil K. Tyagi. Role of Vaccines and Immuno-modulation in Tuberculosis. In: N. K. Mehra and S. K. Sharma and O. P. Sood (eds.), Challenges of MDR/XDR Tuberculosis in India. Round Table Conference Series. 2009. Ranbaxy Science Foundation, New Delhi, India. (Co-first author)

3.    Anil K. Tyagi, Bappaditya Dey and Ruchi JainTuberculosis vaccine development: current status and future expectations. In S. K Sharma and A. Mohon (eds.), Tuberculosis 2nd edition. 2009. 918-946. Jaypee Brothers Medical Publishers, New Delhi, India. (Co-first author)

4.    Anil K. Tyagi, Bappaditya Dey and Ruchi JainDevelopment of vaccine against tuberculosis. In: N. K. Mehra and S. K. Sharma and O. P. Sood (eds.), HIV and Tuberculosis: Co-infection. Round Table Conference Series. 2005. (15) 149-153. Ranbaxy Science Foundation, New Delhi, India. (Co-first author)

5.    Ruchi Jain and Anil K Tyagi. New Technology forces microbes to reveal their secrets. In: T. Satyanarayana and B.N. Johri (eds.). Microbial Diversity: Current Perspectives and Potential Applications, I.K. International Pvt. Ltd., New Delhi. 2005.1053-1074. (First author)

6.    Ruchi Jain and Anil K. Tyagi. Development of candidate vaccines for protection against Tuberculosis. In: Pawan Sharma (eds) Tuberculosis: Current Research Trends. Allied Publishers. New Delhi. 2004. 138-158. (First author)

Manuscripts under Revision: 1 (Kotwal, Shifa et al, Heliyon, Cell Press) - Revision submitted