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Integrated First Degree

B.E.(Biotechnology)
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Prof. Ramendra Kishor Pal

hyderabad Chemical Engineering

Assistant Professor
Department of Chemical Engineering

Biochemical sensors, Biomaterials, Cold Plasma-based disinfection of pathogens, Plasma medicine, Soft electronics
Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India
ramendra.pal@hyderabad.bits-pilani.ac.in
ramendra.k.pal@gmail.com
040-66303779
7307024529
https://www.linkedin.com/in/ramendra-pal/

RESEARCH PROJECTS

ONGOING PROJECTS

Silk-based Flexible Electronics and Sensors

We are developing an all-water-based strategy to create flexible electronics, sensors, and drug-delivery devices for physiological applications. This work is in collaboration with Prof. Srinivasa K Prasad from the Department of Pharmacy @BPHC.
Cold Plasma-based Advanced Oxidation Process

We are studying the effect of cold plasma on the oxidation of antibiotic residues in water. This work is in collaboration with Prof. G. R. Abhijith from the Department of Civil Engineering at IIT Kanpur and Dr. Neethu Bhasker from  KSCSTE.

Non-enzymatic Glutamate Sensors

In this project, we are developing copper nanoparticle-based glutamate sensors. 


Development of Bacteria Detection Sensors

In collaboration with Prof. Debirupa Mitra, we are trying to develop point-of-care diagnostic tools for detecting infection in wounds.

Shape-memory polymers

We are currently studying the effect of water uptake on the actuation performance of shape memory polymers. This work is going on in collaboration with Prof. Punnag Chatterjee from the Department of Mechincal Engineering at IIT Dharwad.

SPONSORED PROJECTS

DBT BME: [2023-2025]

Title: A Point-of-Care Tool for Monitoring Bacterial Infection in Wounds 

Funding Organization: DBT
Amount: Rs. 22,50,000
Role: PI

DBT BME: [Approved for funding]

Title: Development and Validation of Sensor-augmented Pump (SAP) for Glutamate Tracking and Grabbing in Neurological Disorders

Funding Organization: DBT
Amount: Rs. 36,00,000
Role: Co-PI

Cross-disciplinary Research Fund: [2023-2025]

Title: Neurocomputational analyses of electrophysiological recordings using silk-based soft electrodes in noise-induced hearing loss

Funding Organization: BITS Pilani
Amount: Rs. 10,00,000
Role: Co-PI

Additional Competitive Research Grant: Duration: [2022-2024]

Title: Cold Plasma-based Dry and Chemical Residue-free Sanitation of Surfaces

Funding Organization: BITS Pilani
Amount: Rs. 10,00,000
Role: PI

Research Initiation Grant:  [2021-2023]
Title: Silk-based Bioelectronics for Health Monitoring, Modulation, and Therapeutics

Funding Organization: BITS Pilani
Amount: Rs. 2,00,000
Role: PI

RESEARCH INTRESTS

I take an experimental approach to innovate solutions and seek answers to the fundamental questions related to human health and the environment. The broad vision of my research is to gain a deeper understanding of redox processes, develop devices that generate redox species, and probe biological processes using redox methods for monitoring human health and the environment. Toward this end, I focus on three distinct research directions:

Electrochemical sensors for physiological and environmental monitoring

Electrochemical biosensors use electroanalytical (or redox) tools to probe specific biomolecules in multi-analyte systems. Application of electrochemical sensors includes clinical and medical diagnostics, environmental and health monitoring, and food industries. These sensors allow miniaturization, fast read-out, online monitoring, and simultaneous sensing capabilities. This research effort will investigate the modification of biosensor surfaces to impart anti-biofouling properties and smart integration of nanomaterials to improve selectivity and sensitivity of electrochemical sensors.

 

Cold plasma-based therapies and inactivation of pathogens

Cold plasma, the fourth state of matter, refers to partially ionized gas consisting of charged species, excited atoms and molecules, and high-energy photons. The ions and uncharged molecules are at significantly lower temperatures than the electrons, resulting in the plasma staying at a low temperature. The novelty of this technology lies in its non-thermal, economical, versatile, and environmentally friendly nature. The reactive species produced during plasma produce oxidative stresses on biological moieties. The plasma medicine field explores the application of cold plasma for therapeutic purposes. My research aims to understand the specific redox processes occurring in biological systems when exposed to cold plasma and tune the exposure to achieve therapeutic outcomes. Also, various studies have shown the efficacy of cold plasma against Gram-negative and Gram-positive bacteria, yeast, fungi, spores, biofilms, and viruses. I develop cold plasma-generating devices that can inactivate pathogens on surfaces and in air or liquids.

Natural polymer-based bioelectronics

Natural polymers are biocompatible, biodegradable, bio-conformable, and sustainable. They also provide biorecognition, self-repair, and stimuli response, which are beneficial for the systems that interact with biology and ecology.

Bioelectronics employs the principles of electronics to monitor and stimulate biological activities. The prime requirement for bioelectronic systems is biocompatibility. Therefore, natural polymers are material for choice for integration of electronics for biological applications. My research involves developing natural polymer-based functional materials and hybrid microfabrication processes to create biocompatible and biodegradable electronics.

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