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Prof. Ruchi Jain Dey

Assistant Professor
Department of Biological Sciences

Host-pathogen interaction with respect to tuberculosis, Development of novel drugs, therapeutics and vaccination approaches, Novel rapid molecular diagnostics for infectious diseases, Infection induced infertility- exploring new biomarkers and in vitro models
A-115A,
Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India

Education

1. BSc Biochemistry (1998-2001)

Daulat Ram College, University of Delhi

 2. MSc Biochemistry (2001-2003)

Dept of Biochemistry, University of Delhi South Campus 

3. PhD Biochemistry (2003-2009)

Dept of Biochemistry, University of Delhi South Campus

Mentor : Prof. Anil K Tyagi

Work Experience

I have had a diverse and enriching journey of 15 Years post-PhD in the field of research and teaching, spanning over several prestigious institutions (see list below). It began as a Research Associate at the University of Delhi South Campus under the guidance of Prof. Anil K Tyagi. Later, I served as a Scientist-C at the same institution. Seeking international exposure, I pursued a Post-doctorate at the University of Maryland, USA, in the Department of Microbial Pathogenesis at the School of Dentistry. Following that, I joined the renowned Centre for Tuberculosis at Johns Hopkins University School of Medicine in Baltimore, Maryland, USA, where I worked as a Post-doctorate in the HHMI Lab under the mentorship of Prof. William R Bishai for four years. I further expanded my expertise as a Senior Research Fellow at MGH and Broad Institute of MIT and Harvard, collaborating with Prof. Ramnik Xavier. Currently, I hold the esteemed position of Assistant Professor and Ramalingaswami Fellow at the Department of Biological Sciences, BITS Pilani Hyderabad. My extensive experience across multiple institutions has shaped me into a well-rounded researcher with a deep understanding of my field.

1. Research Associate (2008-2010) 

Dept of Biochemistry, University of Delhi South Campus

Lab: Prof. Anil K Tyagi 

 2. Scientist-C (2010-2011) 

Dept of Biochemistry, University of Delhi South Campus 

Lab: Prof. Anil K Tyagi 

 3. Post-doctorate (2012)

Department of Microbial Pathogenesis at School of Dentistry, University of Maryland, USA. 

 4. Post-doctorate (2012-2016)

Center for Tuberculosis, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

HHMI Lab: Prof. William R Bishai 

5.  Senior Research Fellow (May 2016-Nov 2016)

MGH and Broad Institute of MIT and Harvard

Lab: Prof. Ramnik Xavier 

6. Assistant Professor (Level 13A) and Ramalingaswami Fellow (2017 -till date) 

Dept of Biological Sciences, BITS Pilani Hyderabad  
 

Experties of the PI:

A note about the PI:
Dr. Ruchi has more than 17 years of research experience in the area of Tuberculosis (TB) especially TB immunology and vaccinology as well as genetic engineering of mycobacteria for functional analysis of virulence genes as well as construction of genetically engineered live attenuated vaccines and DNA vaccines. She specializes in area of host-pathogen interaction. Especially, her work in the area of bacterial and host cyclic dinucleotide (CDN) signaling and development of host-directed therapy against TB using novel strategies targeting the c-di-AMP pathway for last few years led several ground breaking discoveries and published in leading journals- Nature Medicine, Nature Chemical Biology and Journal of Infectious Diseases. She has a track record of multiple well cited publications in the area of TB vaccines. She is an expert in BSL3 and Animal BSL3 set up and establishing in vitro and animal models (mice and guinea pig) for Tuberculosis infection for testing vaccines and for conducting virulence studies. She is trained at various BSL3/Animal BSL3 facilities at Delhi University, JALMA Agra, Johns Hopkins, Broad Institute of MIT and Harvard during her doctoral and post-doctoral research (2003-2016)