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Dr. Aniruddha Roy

Associate Professor, Department of Pharmacy,
BITS Pilani, Pilani Campus

Drug delivery, Pharmaceutics
Department of Pharmacy, Birla Institute of Technology & Science, Pilani- 333031, Rajasthan. India.
Dr. Aniruddha Roy

 Publication list

# - Corresponding author; * - Equal contributory author 

  1. Kirwale SS, Sharma S, Roy A#. Chitosan, chondroitin sulfate, and hyaluronic acid based in-situ forming scaffold for efficient cell grafting. International Journal of Biological Macromolecules. 2023; 225: 938-51.
  2. Sharma S, Madhyastha H, Kirwale SS, Sakai K, Katakia YT, Majumder S, Roy A#. Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin sulfate-based in-situ forming wound dressing. Carbohydrate Polymers, 2022; 120126. 
  3. Swetha, K.L., Maravajjala, K.S., Li SD, Singh M.S., Roy, A#. Breaking the niche: multidimensional nanotherapeutics for tumor microenvironment modulation. Drug Delivery and Translational Research. 2022; https://doi.org/10.1007/s13346-022-01194-7
  4. Maravajjala, K.S., Swetha, K.L., Roy, A#. pH-responsive nanoparticles for multidimensional combined chemo-immunotherapy of cancer. Journal of Pharmaceutical Sciences. 2022;111(8):2353-2368
  5. Waghule T, Swetha KL, Roy A, Saha RN, Singhvi G. Quality by design assisted optimization of temozolomide loaded PEGylated lyotropic liquid crystals: Investigating various formulation and process variables along with in-vitro characterization. Journal of Molecular Liquids. 2022; 352: 118724
  6. Rapalli VK, Sharma S, Roy A, Singhvi G. Design and dermatokinetic evaluation of Apremilast loaded nanostructured lipid carriers embedded gel for topical delivery: A potential approach for improved permeation and prolong skin deposition. Colloids and Surfaces B: Biointerfaces. 2021; 111945
  7. Sharma S, Madhyastha H, Swetha KL, Maravajjala KS, Singh A, Madhyastha R, Nakajima Y, Roy A#. Development of an in-situ forming, self-healing scaffold for dermal wound healing: in-vitro and in-vivo studies. Materials Science and Engineering: C. 2021; 112263
  8. Rapalli VK, Sharma S, Roy A, Alexander A, Singhvi G. Solid lipid nanocarriers embedded hydrogel for topical delivery of apremilast: In-vitro, ex-vivo, dermatopharmacokinetic and anti-psoriatic evaluation. Journal of Drug Delivery Science and Technology. 2021; 63:102442.
  9. Swetha, K.L., Maravajjala, K.S., Sharma, S., Chowdhury, R., Roy, A#. Development of a tumor extracellular pH-responsive nanocarrier by terminal histidine conjugation in a star shaped poly(lactic-co-glycolic acid). European Polymer Journal. 2021; 147:110337.
  10. Padhye, T., Maravajjala, K.S., Swetha, K.L., Sharma, S., Roy, A#. A comprehensive review of the strategies to improve oral drug absorption with special emphasis on the cellular and molecular mechanisms. Journal of Drug Delivery Science and Technology. 2021; 61:102178.
  11.  Swetha, K.L., Sharma, S., Chowdhury, R., Roy, A#. Disulfiram potentiates docetaxel cytotoxicity in breast cancer cells through enhanced ROS and autophagy. Pharmacological Reports. 2020; 72(6):1749–1765.
  12. Maravajjala KS, Swetha KL, Sharma S, Roy A#. Development of a size-tunable paclitaxel micelle using a microfluidic-based system and evaluation of its in-vitro efficacy and intracellular delivery. Journal of Drug Delivery Science and Technology. 2020; 60:102041.
  13. Rapalli VK, Sharma S, Roy A, Dubey SK, Singhvi G. Curcumin loaded nanostructured lipid carriers for enhanced skin retained topical delivery: optimization, scale-up, in-vitro characterization and assessment of ex-vivo skin deposition. European Journal of Pharmaceutical Sciences, 2020; 152:105438.
  14. Sharma S, Swetha KL, Roy A#. Chitosan-Chondroitin sulfate based polyelectrolyte complex for effective management of chronic wounds. International Journal of Biological Macromolecules, 2019; 132:97-108.
  15. Swetha KL, Roy A#. Tumor heterogeneity and nanoparticle-mediated tumor targeting: the importance of delivery system personalization. Drug Delivery and Translational Research, 2018;8(5):1508-1526.
  16. Lohitesh K, Saini H, Srivastava A, Mukherjee S, Roy A#, Chowdhury R#. Autophagy inhibition potentiates SAHA mediated apoptosis in glioblastoma cells by accumulation of damaged mitochondria. Oncology Reports, 2018;39(6):2787-2796.
  17. Pasha SS, Fageria L, Climent C, Rath NP, Alemany P, Chowdhury R#, Roy A#, Laskar IR#. Evaluation of a Novel Platinum(II)Based AIE Compound-Encapsulated Mesoporous Silica Nanoparticles for Cancer Theranostic Application. Dalton Trans., 2018;47(13):4613-4624.
  18. Roy A, Zhao Y, Yang Y, Szeitz A, Klassen T, Li SD. Selective targeting and therapy of metastatic and multidrug resistant tumors using a long circulating podophyllotoxin nanoparticle. Biomaterials. 2017;137:11-22.
  19. Yang Y*, Roy A*, Zhao Y, Undzys E, Li SD. Comparison of Tumor Penetration of Podophyllotoxin-Carboxymethylcellulose Conjugates with Various Chemical Compositions in Tumor Spheroid Culture and In Vivo Solid Tumor. Bioconjug Chem. 2017;28(5):1505-1518.
  20. Roy A#, Li SD# Modifying the tumor microenvironment using nanoparticle therapeutics. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016;8(6):891-908.
  21. Tang WL, Chen WC, Roy A, Undzys E, Li SD. A Simple and Improved Active Loading Method to Efficiently Encapsulate Staurosporine into Lipid-Based Nanoparticles for Enhanced Therapy of Multidrug Resistant Cancer. Pharm Res. 2016, 33(5); 1104-14.
  22. May JP, Undzys E, Roy A, Li SD. Synthesis of a Gemcitabine Prodrug for Remote Loading into Liposomes and Improved Therapeutic Effect. Bioconjug Chem. 2016, 27(1); 226-37.
  23. Ernsting MJ*, Hoang B*, Roy A*, Murakami M, Undzys E, Li SD. Docetaxel-carboxymethylcellulose nanoparticles target cells via a SPARC and albumin dependent mechanism. Biomaterials. 2015; 59:66-76. (*Equal contributory author)
  24. Roy A, Ernsting MJ, Undzys E, Li SD. A highly tumor-targeted nanoparticle of podophyllotoxin penetrated tumor core and regressed multidrug resistant tumors. Biomaterials. 2015; 52:335-46.
  25. Roy A, Bhattacharyya M, Ernsting MJ, May JP, Li SD. Recent progress in the development of polysaccharide conjugates of docetaxel and paclitaxel. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014;6(4):349-68.
  26. Roy A, Murakami M, Ernsting MJ, Hoang B, Undzys E, Li SD. Carboxymethylcellulose-based and docetaxel-loaded nanoparticles circumvent P-glycoprotein-mediated multidrug resistance. Mol Pharm. 2014 4;11(8):2592-9.
  27. Ernsting MJ, Murakami M, Roy A, Li SD. Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. J Control Release. 2013 Dec 28;172(3):782-94.
  28. Roy A, Singh MS, Upadhyay P, Bhaskar S. Nanoparticle mediated co-delivery of paclitaxel and a TLR-4 agonist results in tumor regression and enhanced immune response in the tumor microenvironment of a mouse model. Int J Pharm. 2013;445(1-2):171-80.
  29. Roy A, Chandra S, Mamilapally S, Upadhyay P, Bhaskar S. Anticancer and immunostimulatory activity by conjugate of paclitaxel and non-toxic derivative of LPS for combined chemo-immunotherapy. Pharm Res. 2012; 29(8):2294-309.
  30. Roy A, Singh MS, Upadhyay P, Bhaskar S. Combined chemo-immunotherapy as a prospective strategy to combat cancer: a nanoparticle based approach. Mol Pharm. 2010 4;7(5):1778-88.
  31. Adhikari D, Samanta SK, Dutta A, Roy A, Vedasiromoni JR and Sen T. In vitro Haemolysis and Lipid Peroxidation inducing activity of Tentacle Extract of the Sea anemone (Parachondylactis indica Dave) on Rat Erythrocyte. Indian Journal of Pharmacology, June 2007, 39 (3), 155-159.