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P. R. Deepa

pilani Biological Sciences

Professor, Department of Biological Sciences, BITS Pilani, Pilani Campus

Applied Biochemistry
Chamber No. 3277-S, Faculty Division III, New Science Block
Department of Biological Sciences,
Birla Institute of Technology & Science, Pilani- 333031, Rajasthan. India.
deepa@pilani.bits-pilani.ac.in
+91-1596-255881
+91-1596-244183

Publications

  • Puri S, Kirad S, Muzaffar-Ur-Rehman M, Mandal SK, Sharma PK, Sankaranarayanan M, Deepa PR. Lipogenic stearoyl-CoA desaturase-1 (SCD1) targeted virtual screening for chemical inhibitors: molecular docking/dynamics simulation and in vitro assessment of anti-NAFLD efficacy. RSC advances. 2024;14(43):31797-808.
  • Kirad S, Puri S, Deepa PR, Sankaranarayanan M. An insight into advances and challenges in the development of potential stearoyl Co-A desaturase 1 inhibitors. RSC advances. 2024;14(41):30487-517.
  • Puri S, Mandal SK, Sharma NK, Pal P, Lamba RP, Miller V, Pal UN, Deepa PR. Biochemical evaluation of wound healing efficacy of cold plasma-conditioned media under different operational conditions. Journal of Physics D: Applied Physics. 2024 Jul 11;57(40):405201.
  • Puri S, Mandal SK, Jain H, Sharma PK, Deepa PR. Comparative bioactivity assessment of bixin pigment and associated phytochemicals extracted from annatto seeds using conventional and green solvents. J Food Drug Anal. 2024 Jun 15;32(2):168-183. doi: 10.38212/2224-6614.3500. 
  • Bansal C, Deepa PR, Agarwal V, Chandra R. A clustering and graph deep learning-based framework for COVID-19 drug repurposing. Expert Systems with Applications. 2024 Sep 1;249:123560.
  • Chauhan S, Joshi T, Adhikari U, Sinha A, Deepa PR, Sharma PK. Desert legumes as sustainable sources of proteins and bioactive peptides: Technological insights into functional food development from underutilized plants. Food and Humanity. 2024 May 1;2:100295.
  • Sharma NK, Pal P, Singh V, Kumar R, Mishra A, Singh M, Lamba RP, Mandal SK, Puri S, Deepa PR, Choyal Y. Pal UN. Development and Characterization of Cold Atmospheric Pressure Plasma Jet Source for Skin Wound Healing Application. In 2023 IEEE Pulsed Power Conference (PPC) 2023 Jun 25 (pp. 1-5). IEEE. 
  • Joshi T, Sehgal H, Puri S, Mahapatra T, Joshi M, Deepa PR, Sharma PK. ML-based technologies in sustainable agro-food production and beyond: Tapping the (semi) arid landscape for bioactives-based product development. Journal of Agriculture and Food Research. 2024 Aug 8:101350.
  • Puri S, Mandal SK, Srivastava A, Agrawal I, Deepa PR. Targeting lipid metabolism in plants for non-animal sources of nutraceuticals towards sustainable food production and scale up. Food Bioscience. 2023 Jul 14:102904.
  • Mandal SK, Puri S, Kumar BK, Muzaffar-Ur-Rehman M, Sharma PK, Sankaranarayanan M, Deepa PR. Targeting lipid-sensing nuclear receptors PPAR (α, γ, β/δ): HTVS and molecular docking/dynamics analysis of pharmacological ligands as potential pan-PPAR agonists. Molecular Diversity. 2023 Jun 6:1-6.
  • Mandal SK, Rehman MM, Katyal A, Rajvanshi K, Kannan M, Garg M, Murugesan S, Deepa PR. In silico anti-viral assessment of phytoconstituents in a traditional (Siddha Medicine) polyherbal formulation–Targeting Mpro and pan-coronavirus post-fusion Spike protein. Journal of Traditional and Complementary Medicine. 2023 Jul 13.
  • Joshi T, Mandal SK, Puri S, Asati V, Deepa PR, Sharma PK. Investigating the antioxidant activity enhancer effect of Cyamopsis tetragonoloba seed extract on phenolic phytochemicals. Frontiers in Plant Science. 2023;14.
  • Chatterjee A, Puri S, Sharma PK, Deepa PR*, Chowdhury S. Nature-inspired Enzyme engineering and sustainable catalysis: biochemical clues from the world of plants and extremophiles. Front Bioeng Biotechnol. 2023;11:1229300. 
  • Joshi T, Deepa PR, Joshi M, Sharma PK. Matters of the desert: A perspective on achieving food and nutrition security through plants of the (semi) arid regions. Journal of Agriculture and Food Research. 2023 Dec 1;14:100725.
  • Joshi T, Sehgal H, Mandal SK, Joshi M, Deepa PR, Sharma PK. Nutraceutical and flavor profiles in underutilized desert legumes of India: gene editing strategies towards sustainable food development. Journal of Plant Biochemistry and Biotechnology. 2023 Mar 29:1-8.
  • Mandal SK, Kumar BK, Sharma PK, Murugesan S, Deepa PR. In silico and in vitro analysis of PPAR–α/γ dual agonists: Comparative evaluation of potential phytochemicals with anti-obesity drug orlistat. Computers in Biology and Medicine. 2022 Jun 28:105796.  
  • Mandal SK, Tare M, Deepa PR. COVID-19 infection and metabolic comorbidities: Mitigating role of nutritional sufficiency and drug–Nutraceutical combinations of vitamin D. Human Nutrition & Metabolism. 2022 Dec 19:200179. 
  • Joshi T, Deepa PR, Sharma PK. Effect of different proportions of phenolics on antioxidant potential: Pointers for bioactive Synergy/Antagonism in foods and nutraceuticals. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. 2022 Dec;92(4):939-46.
  • Asati V, Deepa PR, Sharma PK. Desert legume Prosopis cineraria as a novel source of antioxidant flavonoids/isoflavonoids: Biochemical characterization of edible pods for potential functional food development. Biochemistry and Biophysics Reports. 2022 Mar 1;29:101210.
  • Asati V, Deepa PR, Sharma PK. Silent metabolism and not-so-silent biological activity: possible molecular mechanisms of stress response in edible desert legumes. Journal of Plant Biochemistry and Biotechnology. 2021 Dec;30(4):640-5.
  • Deepa PR, Nalini V, Surianarayanan M, Krishnakumar S. Towards safer non-volatile tissue fixatives: Evaluation of choline-based ionic liquids for fixing ocular tissues. Ecotoxicology and Environmental Safety. 2021 Feb 1;209:111777.
  • Anusha.S.M, Sivanesh. N.E, Deepa P.R, Surianarayanan.M (2020). Understanding the biocalorimetric and respirometric behaviour of co-culture (R. eutropha, P. putida and A. vinelandii) in poly (3-hydroxybutyrate) batch production. Biochemical Engineering Journal, 155, 107334.
  • Anusha S.M, Sivanesh N.E, Hariram. P, Leelaram. S, Ankitha. R, Vignesh. S, Deepa P.R, Surianarayanan M. (2020) Biokinetics of fed-batch production of poly (3-hydroxybutyrate) using microbial co-culture. Appl Microbiol Biotechnol. ;104(3):1077‐1095. 
  • A Tamilselvi, Gladstone Christopher Jayakumar, K Sri Charan, Bindia Sahu, PR Deepa, Swarna V. Kanth, J. Kanagaraj. (2019). Extraction of cellulose from renewable resources and its application in leather finishing. Journal of Cleaner Production 230: 694-699 
  • R Bhuvanasundar,  Nareshkumar NR, Naveen Kumar S, K Coral, PR Deepa, KN Sulochana (2019). Expression, purification and characterization of a biologically active and thermally stable human lysyl oxidase. Indian Journal of Biochemistry & Biophysics Vol. 56  105-116. 
  • Shanmugam BK, Easwaran SN, Lakra R, Deepa PR, Mahadevan S. (2017). Metabolic pathway and role of individual species in the bacterial consortium for biodegradation of azo dye: A biocalorimetric investigation. Chemosphere. 188: 81-89 
  • John A, Vetrivel U, Subramanian K, Deepa PR. (2017). Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands. J Biomol Struct Dyn. 35(6):1350-1366. Epub 2016 Aug 8. 
  • Padma Murali, Deepa PR, Raghavan Subramanyan, Farida Farzana A. J., Nithya Lakshmi M., Murali Raman. (2017). Mathematical Modeling of Coronary Artery Disease (CAD):Analysis Reveals HbA1c and Total Cholesterol to be Significant Risk Predictors, Applied Mathematics, 7 (1): 1-4.
  • Nalini V, Deepa PR, Raguraman R, Khetan V, Reddy MA, Krishnakumar S. (2016). Targeting HMGA2 in Retinoblastoma Cells in vitro Using the Aptamer Strategy. Ocul Oncol Pathol.;2(4):262-269.
  • John A, Umashankar V, Samdani A, Sangeetha M, Krishnakumar S, Deepa PR. (2016). In Silico Structure Prediction of Human Fatty Acid Synthase-Dehydratase: A Plausible Model for Understanding Active Site Interactions. Bioinform Biol Insights. 10:143-54. 
  • S. Leelaram, N.E. Sivanesh, M. Surianarayanan, Deepa PR, S. Ashwath Balaje (2016). Effect of feeding strategies on inulinase production analyzed in a biocalorimeter. Process Biochemistry 51 (6), 692-703.  
  • Venkatesan N, Kanwar JR, Deepa PR, Navaneethakrishnan S, Joseph C, Krishnakumar S.(2016). Targeting HSP90/Survivin using a cell permeable structure based peptido-mimetic shepherdin in retinoblastoma. Chem Biol Interact.252:141-9. 
  • Venkatesan N, Kanwar J, Deepa PR, Khetan V, Crowley TM, Raguraman R, Sugneswari G, Rishi P, Natarajan V, Biswas J, Krishnakumar S. 2016). Clinico-Pathological Association of Delineated miRNAs in Uveal Melanoma with Monosomy 3/Disomy 3 Chromosomal Aberrations. PLoS One. 11(1):e0146128. 
  • Venkatesan N, Deepa PR, Khetan V, Krishnakumar S. (2015). Computational and in vitro Investigation of miRNA-Gene Regulations in Retinoblastoma Pathogenesis: miRNA Mimics Strategy. Bioinform Biol Insights. 9:89-101. 
  • Sangeetha M, Deepa PR, Rishi P, Khetan V, Krishnakumar S. (2015). Global gene deregulations in FASN silenced retinoblastoma cancer cells: molecular and clinico-pathological correlations. J Cell Biochem. 116(11):2676-94.
  • John A, Umashankar V, Krishnakumar S, Deepa PR. (2015). Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase:Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains. Genomics Inform.13(1):15-24.
  •  Venkatesan N, Deepa P, Vasudevan M, Khetan V, Reddy AM, Krishnakumar S. (2014). Integrated Analysis of Dysregulated miRNA-gene Expression in HMGA2-silenced Retinoblastoma Cells. Bioinform Biol Insights. 8:177-91.
  • Bhuvanasundar R, John A, Sulochana KN, Coral K, Deepa PR, Umashankar V. (2014). A molecular model of human Lysyl Oxidase (LOX) with optimal copper orientation in the catalytic cavity for induced fit docking studies with potential modulators. Bioinformation 10(7):406-12.
  • Nalini V, Segu R, Deepa PR, Khetan V, Vasudevan M, Krishnakumar S. (2013). Molecular Insights on Post-chemotherapy Retinoblastoma by Microarray Gene Expression  Analysis. Bioinform Biol Insights 7:289-306.
  •  Vandhana. S., Coral. K., Jayanthi. U., Deepa PR, Krishnakumar. S. (2013). Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors. Biochimica et Biophysica Acta 1831: 1458–1466.
  • Sekar S, Mahadevan S, Deepa PR, Shanmugam BK, Kumar BV, Mandal AB. (2013). The Metabolic Advantage of Choline Lactate in Growth Media: An Experimental Analysis with Staphylococcus lentus. Appl Biochem Biotechnol. 169(2):380-92.
  • Deepa PR, Vandhana S, Krishnakumar S. (2013). Fatty acid synthase inhibition induces differential expression of genes involved in apoptosis and cell proliferation in ocular cancer cells. Nutrition and Cancer. 65(2):311-6.
  • Vandhana S, Lakshmi TS, Indra D, Deepa PR, Krishnakumar S. (2012). Microarray analysis and biochemical correlations of oxidative stress responsive genes in retinoblastoma. Curr. Eye Res. 37(9):830-41.
  • Padma Murali, Deepa PR. (2012). A Bio-mathematical Approach to Evaluate the Risk Burden of Hypertension and Hyperlipidemia in Diabetic Cardiovascular Disease. American Journal of Bioinformatics Research, 2(5).
  • Nalini V, Deepa PR, Deepa M, Khetan V, Reddy AM, Krishnakumar S. (2012). Molecular de-regulation induced by silencing of High Mobility Group Protein A2 gene in retinoblastoma.  Molecular Vision, 18: 2420–2437.
  • Deepa PR, Vandhana S, Jayanthi U, Krishnakumar S. (2012). Therapeutic and toxicologic evaluation of anti-lipogenic agents in cancer cells compared with non-neoplastic cells. Basic Clin Pharmacol Toxicol. 110(6):494-503.
  • Vandhana S, Deepa PR, Jayanthi U, Biswas J, Krishnakumar S. (2011). Clinico-pathological correlations of fatty acid synthase expression in retinoblastoma: an Indian cohort study. Exp Mol Pathol.,90(1):29-37. 
  • Deepa PR, Vandhana S, Muthukumaran S, Umashankar V, Jayanthi U, Krishnakumar S. (2010). Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells. Journal of Ocular Biology, Diseases, and Informatics.,3(4):117-28.
  • Mallikarjuna K, Sundaram CS, Sharma Y, Deepa PR, Khetan V, Gopal L, Biswas J, Sharma T, Krishnakumar S. (2010). Comparative proteomic analysis of differentially expressed proteins in primary retinoblastoma tumors.Proteomics Clin Appl., 4(4):449-63.
  • Vandhana S, Deepa PR, Aparna G, Jayanthi U, Krishnakumar S. (2010). Evaluation of suitable solvents for testing the anti-proliferative activity of triclosan - a hydrophobic drug in cell culture. Indian J Biochem Biophys., 47(3):166-71. 
  • Deepa PR, Nalini V, Mallikarjuna K, Vandhana S, Krishnakumar S. (2009). Oxidative stress in retinoblastoma: correlations with clinicopathologic features and tumor invasiveness. Curr Eye Res., 34(12):1011-8.
  • Deepa, PR, Varalakshmi, P (2006). Exogenous Heparin-Derivative Affords Protection Against Lipid Anomalies and Apoptotic DNA Damage in Experimental Atherogenesis. Vascular Disease Prevention, 3 (2), 107-115(9).
  • Deepa PR, Varalakshmi P.(2006). Favourable modulation of the inflammatory changes in hypercholesterolemic atherogenesis by a low-molecular-weight heparin derivative. Int J Cardiol. 106(3):338-47.
  • Deepa PR, Varalakshmi P. (2006). Influence of a low-molecular-weight heparin derivative on the nitric oxide levels and apoptotic DNA damage in adriamycin-induced cardiac and renal toxicity. Toxicology , 16;217(2-3):176-83.
  • Deepa PR, Varalakshmi P.(2005). Biochemical evaluation of the inflammatory changes in cardiac, hepatic and renal tissues of adriamycin-administered rats and the modulatory role of exogenous heparin-derivative treatment. Chem Biol Interact., 156(2-3):93-100.
  • Deepa PR, Varalakshmi P. (2005). Beneficial cardio-renovascular effects of a low-molecular-weight heparin-derivative on adriamycin-induced glycosaminoglycanuria and tissue lipid abnormalities. Toxicology., 1;211(1-2):77-85.
  • Deepa PR, Varalakshmi P (2005). Atheroprotective effect of exogenous heparin-derivative treatment on the aortic disturbances and lipoprotein oxidation in hypercholesterolemic diet fed rats. Clin Chim Acta., 355(1-2):119-30. 
  • Deepa PR, Varalakshmi P. (2004). Protective effects of certoparin sodium, a low molecular weight heparin derivative, in experimental atherosclerosis. Clin Chim Acta. , 339(1-2):105-15.
  • Deepa PR, Varalakshmi P. (2003). Salubrious effect of low molecular weight heparin on atherogenic diet-induced cardiac, hepatic and renal lipid peroxidation and collapse of antioxidant defences. Mol Cell Biochem. 254(1-2):111-6.
  • Deepa PR, Varalakshmi P. (2003). Protective effect of low molecular weight heparin on oxidative injury and cellular abnormalities in adriamycin-induced cardiac and hepatic toxicity. Chem Biol Interact., 25;146(2):201-10. 
  • Deepa PR, Varalakshmi P. (2003). The cytoprotective role of a low-molecular-weight heparin fragment studied in an experimental model of glomerulotoxicity. Eur J Pharmacol., 8;478(2-3):199-205. 
  • Deepa PR, Varalakshmi P. (2003) Favourable influence of low molecular weight heparin in mitigating the peroxidative membrane damage induced by a cytotoxic agent and an atherogenic diet. Hum Exp Toxicol. 22(5):229-35. 

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