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Gautam Singhvi

Associate Professor, Department of Pharmacy,
BITS Pilani, Pilani Campus

Pharmaceutics and Pharmacokinetics
Department of Pharmacy, Birla Institute of Technology & Science, Pilani- 333031, Rajasthan. India.

Journal Publications

1.    Gorantla S, Puppala ER, Naidu VG, Saha RN, Singhvi G*. Hyaluronic acid-coated proglycosomes for topical delivery of tofacitinib in rheumatoid arthritis condition: Formulation design, in vitro, ex vivo characterization, and in vivo efficacy studies. International Journal of Biological Macromolecules. 2023 Jan 1; 224:207-22. Impact factor: 8.025.

2.  Waghule T, Saha RN, Singhvi G*. Exploring microfluidics and membrane extrusion for the formulation of temozolomide-loaded liposomes: investigating the effect of formulation and process variables. Journal of Liposome Research. 2022 Nov 11:1-3. Impact factor: 5.586.

3.    Priya S, Desai VM, Singhvi G*. Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery. ACS omega. 2023, 8, 1, 74–86. Published on Dec 20, 2022. Impact factor: 4.132.

4.   Tomar Y, Gorantla S, Singhvi G*. Insight into the pivotal role of signaling pathways in psoriasis pathogenesis, potential therapeutic molecules and drug delivery approaches. Drug Discovery Today. 2022 Dec 5:103465. Impact factor: 8.369

5.    Donthi MR, Munnangi SR, Krishna KV, Marathe SA, Saha RN, Singhvi G, Dubey SK. Formulating Ternary Inclusion Complex of Sorafenib Tosylate Using β-Cyclodextrin and Hydrophilic Polymers: Physicochemical Characterization and In Vitro Assessment. AAPS PharmSciTech. 2022 Sep 15;23(7):254. Impact factor: 4.026

6.    Waghule T, Saha RN, Alexander A, Singhvi G*. Tailoring the multi-functional properties of phospholipids for simple to complex self-assemblies. Journal of Controlled Release. 2022 Sep 1;349:460-74. Impact factor: 11.467

7.    Dey A, Singhvi G, Puri A, Kesharwani P, Dubey SK. An insight into photodynamic therapy towards treating major dermatological conditions. Journal of Drug Delivery Science and Technology. 2022 Aug 30:103751. Impact factor: 5.062

8.   Chandra NS, Gorantla S, Priya S, Singhvi G*. Insight on updates in polysaccharides for ocular drug delivery. Carbohydrate Polymers. 2022 Aug 22:120014. Impact factor: 10.723

9.   Mahmood A, Rapalli VK, Gorantla S, Waghule T, Singhvi G*. Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical delivery: QbD-driven design, optimization, and in vitro and ex vivo evaluations. Drug Delivery and Translational Research. 2022 May;12(5):1118-35. Impact factor: 5.571

10. Waghule T, Swetha KL, Roy A, Saha RN, Singhvi G*. Quality by design assisted optimization of temozolomide loaded PEGylated lyotropic liquid crystals: investigating various formulation and process variables along with in-vitro characterization. Journal of molecular liquids. 2022 Apr 15;352:118724. Impact factor: 6.633

11. Gorantla S, Batra U, Samshritha RN, Puppala ER, Waghule T, Naidu VG, Singhvi G*. Emerging trends in microneedle-based drug delivery strategies for the treatment of rheumatoid arthritis. Expert Opinion on Drug Delivery. 2022 Apr 3;19(4):395-407. Impact factor: 8.129

12. Jain R, Dubey SK, Singhvi G*. The Hedgehog pathway and its inhibitors: Emerging therapeutic approaches for basal cell carcinoma. Drug Discovery Today. 2022 Apr 1;27(4):1176-83. Impact factor: 8.369

13. Gorantla S, Saha RN, Singhvi G*. Exploring the affluent potential of glyceryl mono oleate–myristol liquid crystal nanoparticles mediated localized topical delivery of Tofacitinib: Study of systematic QbD, skin deposition and dermal pharmacokinetics assessment. Journal of Molecular Liquids. 2022 Jan 15;346:117053. Impact factor: 6.633

14. Rapalli VK, Mahmood A, Waghule T, Gorantla S, Kumar Dubey S, Alexander A, Singhvi G*. Revisiting techniques to evaluate drug permeation through skin. Expert Opinion on Drug Delivery. 2021 Dec 2;18(12):1829-42. Impact factor: 8.129

15. Gorantla S, Wadhwa G, Jain S, Sankar S, Nuwal K, Mahmood A, Dubey SK, Taliyan R, Kesharwani P, Singhvi G*. Recent advances in nanocarriers for nutrient delivery. Drug Delivery and Translational Research. 2021 Nov 29:1-26. Impact factor: 5.571

16. Gorantla S, Gorantla G, Saha RN, Singhvi G*. CD44 receptor-targeted novel drug delivery strategies for rheumatoid arthritis therapy. Expert Opinion on Drug Delivery. 2021 Nov 2;18(11):1553-7. . Impact factor: 8.129

17. Dabholkar N, Gorantla S, Dubey SK, Alexander A, Taliyan R, Singhvi G*. Repurposing methylene blue in the management of COVID-19: Mechanistic aspects and clinical investigations. Biomedicine & Pharmacotherapy. 2021 Oct 1;142:112023. Impact factor: 7.419

18. Rapalli VK, Sharma S, Roy A, Singhvi G. Design and dermatokinetic evaluation of Apremilast loaded nanostructured lipid carriers embedded gel for topical delivery: A potential approach for improved permeation and prolong skin deposition. Colloids and Surfaces B: Biointerfaces. 2021 Oct 1;206:111945. Impact factor: 5.999

19. Gorantla S, Dabholkar N, Sharma S, Rapalli VK, Alexander A, Singhvi G*. Chitosan-based microneedles as a potential platform for drug delivery through the skin: Trends and regulatory aspects. International Journal of Biological Macromolecules. 2021 Aug 1;184:438-53. Impact factor: 8.025.

20. Rapalli VK, Sharma S, Roy A, Alexander A, Singhvi G*. Solid lipid nanocarriers embedded hydrogel for topical delivery of apremilast: In-vitro, ex-vivo, dermatopharmacokinetic and anti-psoriatic evaluation. Journal of Drug Delivery Science and Technology. 2021 Jun 1;63:102442. Impact factor: 5.062

21. Waghule T, Patil S, Rapalli VK, Girdhar V, Gorantla S, Kumar Dubey S, Saha RN, Singhvi G*. Improved skin-permeated diclofenac-loaded lyotropic liquid crystal nanoparticles: QbD-driven industrial feasible process and assessment of skin deposition. Liquid crystals. 2021 May 28;48(7):991-1009. Impact factor: 2.676

22. Dabholkar N, Rapalli VK, Singhvi G*. Potential herbal constituents for psoriasis treatment as protective and effective therapy. Phytotherapy Research. 2021 May;35(5):2429-44. Impact factor: 6.388

23. Waghule T, Rapalli VK, Singhvi G*, Gorantla S, Khosa A, Dubey SK, Saha RN. Design of temozolomide-loaded proliposomes and lipid crystal nanoparticles with industrial feasible approaches: comparative assessment of drug loading, entrapment efficiency, and stability at plasma pH. Journal of liposome research. 2021 Apr 3;31(2):158-68. Impact factor: 5.586

24. Rastogi M, Saha RN, Alexander A, Singhvi G, Puri A, Dubey SK. Role of stealth lipids in nanomedicine-based drug carriers. Chemistry and Physics of Lipids. 2021 Mar 1;235:105036. Impact factor: 3.57

25. Rapalli VK, Banerjee S, Khan S, Jha PN, Gupta G, Dua K, Hasnain MS, Nayak AK, Dubey SK, Singhvi G*. QbD-driven formulation development and evaluation of topical hydrogel containing ketoconazole loaded cubosomes. Materials Science and Engineering: C. 2021 Feb 1;119:111548. Impact factor: 7.328

26. Rapalli VK, Waghule T, Gorantla S, Dubey SK, Saha RN, Singhvi G*. Psoriasis: pathological mechanisms, current pharmacological therapies, and emerging drug delivery systems. Drug Discovery Today. 2020 Dec 1;25(12):2212-26. Impact factor: 8.369

27. Waghule T, Gorantla S, Rapalli VK, Shah P, Dubey SK, Saha RN, Singhvi G*. Emerging trends in topical delivery of curcumin through lipid nanocarriers: effectiveness in skin disorders. AAPS PharmSciTech. 2020 Oct;21:1-2. Impact factor: 4.026

28. Rapalli VK, Kaul V, Waghule T, Gorantla S, Sharma S, Roy A, Dubey SK, Singhvi G*. Curcumin loaded nanostructured lipid carriers for enhanced skin retained topical delivery: optimization, scale-up, in-vitro characterization and assessment of ex-vivo skin deposition. European Journal of Pharmaceutical Sciences. 2020 Sep 1;152:105438. Impact factor: 5.112

29. Gorantla S, Singhvi G*, Rapalli VK, Waghule T, Dubey SK, Saha RN. Targeted drug-delivery systems in the treatment of rheumatoid arthritis: recent advancement and clinical status. Therapeutic Delivery. 2020 Apr;11(4):269-84.

30. Hejmady S, Singhvi G, Saha RN, Dubey SK. Regulatory aspects in process development and scale-up of nanopharmaceuticals. Therapeutic Delivery. 2020 Jun;11(6):341-3.

31. Gorantla S, Rapalli VK, Waghule T, Singh PP, Dubey SK, Saha RN, Singhvi G*. Nanocarriers for ocular drug delivery: Current status and translational opportunity. RSC advances. 2020;10(46):27835-55. Impact factor: 4.036

32. Waghule T, Sankar S, Rapalli VK, Gorantla S, Dubey SK, Chellappan DK, Dua K, Singhvi G*. Emerging role of nanocarriers based topical delivery of anti‐fungal agents in combating growing fungal infections. Dermatologic therapy. 2020 Nov;33(6):e13905. Impact factor: 3.858

33. Waghule T, Rapalli VK, Singhvi G, Manchanda P, Hans N, Dubey SK, Hasnain MS, Nayak AK. Voriconazole loaded nanostructured lipid carriers based topical delivery system: QbD based designing, characterization, in-vitro and ex-vivo evaluation. Journal of Drug Delivery Science and Technology. 2019 Aug 1;52:303-15. Impact factor: 5.062

34. Singhvi G, Manchanda P, Hans N, Dubey SK, Gupta G. Microsponge: an emerging drug delivery strategy. Drug development research. 2019 Mar;80(2):200-8. Impact factor: 5.004

35. Waghule T, Singhvi G*, Dubey SK, Pandey MM, Gupta G, Singh M, Dua K. Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomedicine & pharmacotherapy. 2019 Jan 1;109:1249-58. Impact factor: 7.419

36. Rapalli VK, Singhvi G, Dubey SK, Gupta G, Chellappan DK, Dua K. Emerging landscape in psoriasis management: from topical application to targeting biomolecules. Biomedicine & Pharmacotherapy. 2018 Oct 1;106:707-13. Impact factor: 7.419

37. Girdhar V, Patil S, Banerjee S, Singhvi G. Nanocarriers for drug delivery: mini review. Current Nanomedicine (Formerly: Recent Patents on Nanomedicine). 2018 Aug 1;8(2):88-99.

38. Gautam Singhvi, Vipin KumarRavi Ukawala and Ranendra Narayan Saha. Development of Bioanalytical HPLC Method for Estimation of Milnacipran Hydrochloride in Rabbit Plasma Using Solid Phase Extraction Technique and its Application in Pharmacokinetic Investigation. Current Pharmaceutical Analysis, 2017; 13(5):574 – 580 Impact factor: 0.743

39. Gautam Singhvi, Vipin Kumar Shukla, Ravi Ukawala, Gautham Gampa, Ranendra N. Saha. Development of a new, rapid and sensitive HPTLC method for estimation of Milnacipran in bulk, formulation and compatibility study. Arabian Journal of Chemistry, 2017; 10(2):S2417-S2423. Impact factor: 6.212

40. Saswata Banerjee, Gautam Singhvi, Archana Khosa. In vitro lipolysis: an indispensable tool for the development of ivivc of lipid based drug delivery systems. Drug Delivery Letters, 2017; 7(3):151-156.

41. Satish S. Reddi, Gautam Singhvi, Archana Khosa, Kowthavarapu V Krishna , Ranendra N. Saha. Determination of venlafaxine in bulk and pharmaceutical formulations using stability indicating RP-HPLC method with UV detector. Current Pharmaceutical Analysis, 14 , 2017.

42. Gautam Singhvi. In-vitro and in-vivo correlations [ivivcs] for lipid based nanoformulations. Drug Delivery Letters, 2017; 7(3):150.

43. Gautam Singhvi, Abhishek Shah, Nilesh Yadav,  Ranendra N. Saha.  Prediction of in vivo plasma concentration–timeprofile from in vitro release data of designed formulations of milnacipran using numerical convolution method. Drug Development and Industrial Pharmacy, 2015;41(1):105-108. Impact factor: 3.727

44. Gautam Singhvi, Abhishek Shah, Nilesh Yadav, Ranendra N. Saha. Study the effect of formulation variables on drug release from hydrophilic matrix tablets of milnacipran and prediction of in-vivo plasma profile. Pharmaceutical Development and Technology. 2014, 19(6), 708-716. Impact factor: 3.915

45. Gautam Singhvi, Gautham Gampa, Nilesh Yadav, Vipin Kumar Shukla, Ravi Ukawala. Design and evaluation of rapid disintegrating tablet of Racecadotril with enhanced in-vitro dissolution achieved by solid dispersion technique. Indian Journal of Pharmaceutical Education and Research, 2013, 47(3), 56-63.


Books Chapters

  1. Joseph E, Singhvi G*. Multifunctional nanocrystals for cancer therapy: A potential nanocarrier. In: Grumezescu A, editor. Nanomaterials for Drug Delivery and Therapy. William Andrew Publishing; Elsevier, 2019. p. 91–116.
  2. Rapalli VK, Khosa A, Singhvi G*, Girdhar V, Jain R, Dubey SK. Application of QbD Principles in Nanocarrier-Based Drug Delivery Systems. Beg S, Hasnain MS, editors. Pharmaceutical Quality by Design. Elsevier Inc.; 2019. 255–296 p.
  3. Singhvi G*, krishna RV, Krishna KV, Dubey SK. Alginate: drug delivery and application. Alginates: Versatile Polymers in Biomedical Applications and Therapeutics.  In: Hasnain MS, Nayak AK, editors. Alginates Versatile Polymers in Biomedical Applications and Therapeutics. 1st ed. Canada: Apple Academic Press; 2019. p. 307–34.
  4. Joseph E, Singhvi G*, Banerjee S. Nanoparticulate Drug Delivery Systems for Brain Targeting. In: Keservani R, Sharma A, Kesharwani R, editors. Nanocarriers for Brain Targeting Principles and Applications. 1st ed. Canada: Apple Academic Press; 2020. p. 207–36.
  5.  Hinge N, Pandey MM, Singhvi G, Gupta G, Mehta M, Satija S, et al. Nanomedicine advances in cancer therapy. In: Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering. Elsevier Inc.; 2020. p. 219–53.
  6. Singhvi G*, Rapalli VK, Nagpal S, Dubey SK, Saha RN. Nanocarriers as Potential Targeted Drug Delivery for Cancer Therapy. In: Nanoscience in Medicine. Springer, Cham; 2020. p. 51–88.
  7. Singhvi G, Hejmady S, Rapalli VK, Dubey SK, Dubey S. Nanocarriers for topical delivery in psoriasis. In: Shegokar R, editor. Delivery of Drugs. Germany: Elsevier Inc.; 2020. p. 75–96.
  8. Mahmood A, Singhvi G, Manchanda P, Pandey MM, Dubey SK, Gupta G, Singhvi G*. Applications of 3D printing for the advancement of oral dosage forms. In: Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering. Elsevier; 2020. p. 39–57.
  9. Singhvi G*, Rapalli VK, Waghule T, Gorantla S, et al. Microparticulate drug delivery systems for targeting respiratory diseases. In: Dua K, editor. Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems. Academic Press; Elsevier, 2020. p. 337–57.
  10. Girdhar V, Patil S, Dubey SK, Singhvi G*. Pharmaceutical Applications of Gelatin. In: Nayak AK, Hasnain MS, Pal D, editors. Natural Polymers for Pharmaceutical Applications. Apple Academic Press; 2019. p. 24.
  11. Singhvi G*, Hans N, Shiva N, Kumar Dubey S. Xanthan gum in drug delivery applications. In: Hasnain MS, Nayak AK, editors. Natural Polysaccharides in Drug Delivery and Biomedical Applications. Academic Press; Elsevier, 2019. p. 121–44.
  12. Batra U, Waghule T, Saha RN, Singhvi G. Liposomal Drug Delivery. Nanoparticles and Nanocarriers Based Pharmaceutical Formulations. 2022 Dec 9:303.
  13. Bhansali M, Dabholkar N, Swetha P, Dubey SK, Singhvi G. Solid oral controlled-release formulations. InModeling and Control of Drug Delivery Systems 2021 Jan 1 (pp. 313-331). Academic Press.
  14. Dabholkar N, Swetha P, Bhansali M, Dubey SK, Singhvi G. Advanced Solid Oral Controlled-Release Formulations. InModeling and Control of Drug Delivery Systems 2021 Jan 1 (pp. 333-349). Academic Press.
  15. Singhvi G, Hejmady S, Rapalli VK, Dubey SK, Dubey S. Nanocarriers for topical delivery in psoriasis. InDelivery of drugs 2020 Jan 1 (pp. 75-96). Elsevier.