results 217-228 of 557
Thermodynamically-Consistent Interface Model of Multi-Phase Flow In Disordered Media: A Theoretical and Numerical Study of Upscaling
04/09/2023
Inventors: Subhadeep Roy
This paper presents a thermodynamically-consistent interface model for studying multi-phase flow in disordered media, with a focus on theoretical and numerical upscaling methods. The model addresses the complex interactions between different fluid phases and their flow through heterogeneous or porous media. It ensures thermodynamic consistency in the description of these...
This paper presents a thermodynamically-consistent interface model for studying multi-phase flow in disordered media, with a focus on theoretical and numerical upscaling methods. The model addresses the complex interactions between different fluid phases and their flow through heterogeneous or porous media. It ensures thermodynamic consistency in the description of these interactions and provides a framework for scaling up from microscopic to macroscopic levels. The study includes the development of mathematical models, numerical simulations, and analysis of upscaling techniques to predict large-scale behavior based on detailed, localized observations. The goal is to improve understanding and prediction of multi-phase flow dynamics in various applications, such as in geological formations and industrial processes. (Physics)
Riboflavin-Polymeric Ocular Patch: An Alternative Approach for Collagen Crosslinking Procedure in Keratoconus
25/10/2023
Inventors: Nirmal J, Onkar Kulkarni and Debashish Das
This paper explores the use of a riboflavin-polymeric ocular patch as an alternative method for collagen crosslinking in the treatment of keratoconus. The riboflavin-polymeric patch is designed to enhance the crosslinking process, which strengthens the corneal tissue and stabilizes the condition. The study involves the development of the patch, its...
This paper explores the use of a riboflavin-polymeric ocular patch as an alternative method for collagen crosslinking in the treatment of keratoconus. The riboflavin-polymeric patch is designed to enhance the crosslinking process, which strengthens the corneal tissue and stabilizes the condition. The study involves the development of the patch, its application to the cornea, and an evaluation of its effectiveness in improving corneal rigidity and visual outcomes. The research aims to provide a more convenient, potentially safer, and effective alternative to traditional collagen crosslinking techniques, offering a new approach for managing keratoconus. (Pharmacy)
Determining the Safety and Ocular Pharmacokinetics of the NCE Formulation
09/05/2023
Inventors: Nirmal J
This paper investigates the safety and ocular pharmacokinetics of a new chemical entity (NCE) formulation. The study aims to assess the safety profile and how the formulation behaves within the eye after administration. It includes evaluations of potential side effects, systemic exposure, and the distribution, absorption, metabolism, and elimination of...
This paper investigates the safety and ocular pharmacokinetics of a new chemical entity (NCE) formulation. The study aims to assess the safety profile and how the formulation behaves within the eye after administration. It includes evaluations of potential side effects, systemic exposure, and the distribution, absorption, metabolism, and elimination of the NCE in ocular tissues. The research involves preclinical or clinical trials to ensure that the formulation is safe for use and effective in delivering therapeutic agents to the targeted ocular tissues. The goal is to provide comprehensive data to support the formulation’s approval and clinical use. (Pharmacy)
Designing a Low-Cost Additive Manufacturing Technology for Magnesium-Based Implants
23/11/2023
Inventors: Ravi Shanker Vidyarthy, Pavan Kumar P and Maheshwar Lakki Reddy
This paper focuses on designing a low-cost additive manufacturing technology for producing magnesium-based implants. The study aims to develop an affordable and efficient method for creating high-quality implants using additive manufacturing techniques. It involves optimizing the manufacturing process to handle magnesium, a material with desirable properties for implants due to...
This paper focuses on designing a low-cost additive manufacturing technology for producing magnesium-based implants. The study aims to develop an affordable and efficient method for creating high-quality implants using additive manufacturing techniques. It involves optimizing the manufacturing process to handle magnesium, a material with desirable properties for implants due to its biocompatibility and biodegradability. The research addresses challenges related to material handling, process control, and cost reduction while ensuring the implants meet required performance and safety standards. The goal is to advance the accessibility and application of magnesium-based implants in medical treatments. (Mechanical Engineering)
Development of Robotic-Milling System using Topology Optimization Method
10/11/2023
Inventors: Arshad Javed, Kundan Kumar Singh and Abhishek Sarkar
This paper details the development of a robotic-milling system enhanced by topology optimization methods. The system integrates robotic arms with advanced milling technology to achieve precise and efficient material removal. Topology optimization is used to design and optimize the tool paths and structures, improving performance and material efficiency. The study...
This paper details the development of a robotic-milling system enhanced by topology optimization methods. The system integrates robotic arms with advanced milling technology to achieve precise and efficient material removal. Topology optimization is used to design and optimize the tool paths and structures, improving performance and material efficiency. The study covers the design and implementation of the robotic-milling system, including the application of topology optimization algorithms to optimize milling patterns and tool configurations. The goal is to enhance manufacturing processes by combining robotics and computational optimization techniques, leading to more efficient, accurate, and adaptable machining solutions. (Mechanical Engineering)
Integrated Physical-Biological Treatment of Biopharmaceutical Fermentation Wastewater for Ensuring Environmental Safety and Circular Economy
10/11/2023
Inventors: P Sankar Ganesh, Raja Raja Murari and Mithun Madal
This paper explores an integrated physical-biological treatment approach for managing biopharmaceutical fermentation wastewater, aiming to ensure environmental safety and promote a circular economy. The study combines physical methods, such as filtration and adsorption, with biological processes, including microbial degradation and bioremediation, to effectively treat wastewater generated during biopharmaceutical production. It...
This paper explores an integrated physical-biological treatment approach for managing biopharmaceutical fermentation wastewater, aiming to ensure environmental safety and promote a circular economy. The study combines physical methods, such as filtration and adsorption, with biological processes, including microbial degradation and bioremediation, to effectively treat wastewater generated during biopharmaceutical production. It assesses the efficiency of this combined approach in removing contaminants, reducing environmental impact, and recovering valuable by-products. The research highlights how this integrated treatment strategy supports sustainability goals by improving waste management practices and contributing to a circular economy in the biopharmaceutical industry. (Biological Science)
Novel POC diagnostic device for Biomarker Detection
29/11/2023
Inventors: Sanket Goel
This paper presents the development of a novel point-of-care (POC) diagnostic device specifically designed for biomarker detection. The device aims to offer rapid, accurate, and user-friendly testing for various biomarkers, which are crucial for diagnosing and monitoring health conditions. The study covers the design and engineering aspects of the device,...
This paper presents the development of a novel point-of-care (POC) diagnostic device specifically designed for biomarker detection. The device aims to offer rapid, accurate, and user-friendly testing for various biomarkers, which are crucial for diagnosing and monitoring health conditions. The study covers the design and engineering aspects of the device, including the integration of advanced sensing technologies, sample handling mechanisms, and data processing capabilities. It also evaluates the device's performance in terms of sensitivity, specificity, and ease of use. The goal is to enhance diagnostic capabilities in clinical and non-clinical settings, improving patient care and management. (EEE)
Preclinical Development of Long Acting Subconjunctival Steroid-Sparing Agent to Treat Posterior Uveitis
10/11/2023
Inventors: Nirmal J, Onkar Kulkarni and Soumyava Basu
This paper discusses the preclinical development of a long-acting subconjunctival steroid-sparing agent for treating posterior uveitis. The study focuses on creating and evaluating a novel treatment that reduces the need for systemic steroids, which can have significant side effects. It involves the formulation of the agent for sustained release, testing...
This paper discusses the preclinical development of a long-acting subconjunctival steroid-sparing agent for treating posterior uveitis. The study focuses on creating and evaluating a novel treatment that reduces the need for systemic steroids, which can have significant side effects. It involves the formulation of the agent for sustained release, testing its efficacy and safety in preclinical models, and assessing its potential to control inflammation and prevent disease progression in posterior uveitis. The aim is to provide an effective, localized treatment option that minimizes systemic steroid use and improves patient outcomes. (Pharmacy)
Designing near-infrared Fluorescent Probes for Detection of Mycotoxins in Agricultural Crops and Food Items
17/11/2023
Inventors: Nilanjan Dey
This paper focuses on designing near-infrared (NIR) fluorescent probes for detecting mycotoxins in agricultural crops and food items. Mycotoxins are toxic compounds produced by certain fungi, and their presence in food can pose serious health risks. The study involves developing NIR fluorescent probes that offer high sensitivity and specificity for...
This paper focuses on designing near-infrared (NIR) fluorescent probes for detecting mycotoxins in agricultural crops and food items. Mycotoxins are toxic compounds produced by certain fungi, and their presence in food can pose serious health risks. The study involves developing NIR fluorescent probes that offer high sensitivity and specificity for mycotoxin detection, enabling accurate and rapid analysis. The paper details the design process, including probe synthesis, optimization of fluorescence properties, and validation of the probes' effectiveness in detecting mycotoxins in various food samples. The goal is to improve food safety and quality control through advanced detection methods. (Chemistry)
Development of a Novel POC Diagnostic Device
29/11/2023
Inventors: Sanket Goel
This paper focuses on the development of a novel point-of-care (POC) diagnostic device. The device is designed to provide rapid, accurate, and reliable diagnostic results in various healthcare settings. The study covers the device’s design and engineering, including the integration of advanced sensors, sample processing mechanisms, and data analysis tools....
This paper focuses on the development of a novel point-of-care (POC) diagnostic device. The device is designed to provide rapid, accurate, and reliable diagnostic results in various healthcare settings. The study covers the device’s design and engineering, including the integration of advanced sensors, sample processing mechanisms, and data analysis tools. It emphasizes the device’s potential to improve patient outcomes by enabling timely diagnosis and management of diseases. The research also evaluates the device's performance through testing and validation to ensure its effectiveness and reliability in real-world applications. (EEE)
The Neuroprotective Effect of Vitamin D3 Involves a Phosphatidyl-Inositol-3 Kinase Pathway Activation to Enhance Alpha7 Nicotinic Acetylcholine Receptor Function in Schizophrenia
09/11/2023
Inventors: Pragya Komal
This paper investigates the neuroprotective effects of Vitamin D3 and its involvement in enhancing alpha7 nicotinic acetylcholine receptor (α7 nAChR) function in schizophrenia. The study explores how Vitamin D3 activates the phosphatidyl-inositol-3 kinase (PI3K) pathway, which is crucial for neuroprotection and cognitive function. By examining the interaction between Vitamin D3,...
This paper investigates the neuroprotective effects of Vitamin D3 and its involvement in enhancing alpha7 nicotinic acetylcholine receptor (α7 nAChR) function in schizophrenia. The study explores how Vitamin D3 activates the phosphatidyl-inositol-3 kinase (PI3K) pathway, which is crucial for neuroprotection and cognitive function. By examining the interaction between Vitamin D3, the PI3K pathway, and α7 nAChR, the research aims to elucidate mechanisms through which Vitamin D3 may offer therapeutic benefits in schizophrenia, potentially improving symptoms and cognitive deficits associated with the disorder. (Biological Science)
Uncertainty Principles in Generalized Function Spaces: Theory and Applications
10/10/2023
Inventors: Manish Kumar
This paper explores uncertainty principles in generalized function spaces, focusing on both theoretical aspects and practical applications. Uncertainty principles typically describe the trade-off between the precision of a function's representation in time and frequency domains. The study extends these principles to generalized function spaces, which encompass a broader range of...
This paper explores uncertainty principles in generalized function spaces, focusing on both theoretical aspects and practical applications. Uncertainty principles typically describe the trade-off between the precision of a function's representation in time and frequency domains. The study extends these principles to generalized function spaces, which encompass a broader range of mathematical functions and distributions. It examines the theoretical foundations of these principles, including their mathematical proofs and implications. The paper also discusses practical applications in areas such as signal processing, quantum mechanics, and applied mathematics, where understanding uncertainty is crucial for accurate modeling and analysis. (Mathematics)
An Institute of Eminence
