results 493-504 of 557
Modeling Travel Time for Two-lane Highways
26/09/2023
Inventors: Durgesh Vikram
Travel time for two-lane highways can be effectively predicted and analyzed through advanced modeling techniques, allowing transportation professionals to make informed decisions regarding route planning, traffic management, and infrastructure development. By employing sophisticated algorithms that consider various factors such as road geometry, traffic volume, and speed limits, these models can...
Travel time for two-lane highways can be effectively predicted and analyzed through advanced modeling techniques, allowing transportation professionals to make informed decisions regarding route planning, traffic management, and infrastructure development. By employing sophisticated algorithms that consider various factors such as road geometry, traffic volume, and speed limits, these models can provide accurate estimates of travel duration, enabling stakeholders to optimize roadway performance and enhance overall transportation efficiency. (Civil Engineering)
Design and Synthesis of Inhibitors of Mycobactgerium tuberculosis sigma factor RNAP protein-protein interaction as potential Antimycobacterial Agents
27/12/2021
Inventors: Sandeep Sundriyal, Syamantak Majumder
The main objective of the research project is to create novel inhibitors specifically tailored to target the protein-protein interaction involving the sigma factor RNA polymerase of Mycobacterium tuberculosis. By focusing on designing and synthesizing these inhibitors, the ultimate goal is to develop effective antimycobacterial agents that can combat tuberculosis infections...
The main objective of the research project is to create novel inhibitors specifically tailored to target the protein-protein interaction involving the sigma factor RNA polymerase of Mycobacterium tuberculosis. By focusing on designing and synthesizing these inhibitors, the ultimate goal is to develop effective antimycobacterial agents that can combat tuberculosis infections more efficiently. This approach involves studying the molecular mechanisms involved in the interaction process and formulating compounds that can disrupt this crucial pathway, ultimately leading to the identification of potential drug candidates for further testing and development in the fight against tuberculosis. (Pharmacy)
Tweaks of Triplet State Photochemistry for Human and Disease Research
27/12/2022
Inventors: Avik Kumar Pati
The optimization of triplet state photochemistry presents promising opportunities for advancing research in both human health and disease-related studies. These subtle adjustments in the mechanisms of triplet state reactions could significantly impact the field, offering new insights into biological processes and potential therapeutic interventions. By delving deeper into the intricacies...
The optimization of triplet state photochemistry presents promising opportunities for advancing research in both human health and disease-related studies. These subtle adjustments in the mechanisms of triplet state reactions could significantly impact the field, offering new insights into biological processes and potential therapeutic interventions. By delving deeper into the intricacies of this photochemical process, researchers aim to unlock a deeper understanding of various conditions, paving the way for innovative treatments and diagnostic tools. This nuanced approach underscores the critical role that photochemistry plays in shaping the landscape of medical research and its implications for human well-being. (Chemistry)
Understanding the role of Nuclear Membrane associated proteins under differential flow dynamics driving EMT and survival of tumor cells
27/06/2023
Inventors: Sudeshna Mukherjee, Venkatesh K P
In this study, we aim to investigate the intricate mechanisms governing the functions of nuclear membrane associated proteins in response to varying flow dynamics, particularly in driving the processes of epithelial-mesenchymal transition (EMT) and promoting the survival of tumor cells. Our research seeks to shed light on how these proteins...
In this study, we aim to investigate the intricate mechanisms governing the functions of nuclear membrane associated proteins in response to varying flow dynamics, particularly in driving the processes of epithelial-mesenchymal transition (EMT) and promoting the survival of tumor cells. Our research seeks to shed light on how these proteins interact under different fluid conditions and their crucial roles in dictating the behavior and fate of cancer cells. By exploring these relationships, we hope to enhance our understanding of the molecular events that underlie tumor progression and identify potential targets for therapeutic interventions. (Biological Sciences)
On the theoretical studies of Vortex Electron impact scattering and ionization of atoms and molecules
28/01/2022
Inventors: Rakesh Choubisa
The theoretical studies focusing on vortex electron impact scattering and ionization of atoms and molecules investigate the intricate interactions between charged particles and matter, shedding light on the fundamental processes that drive atomic and molecular dynamics in the realm of quantum mechanics. By exploring the complex mechanisms of vortex electron...
The theoretical studies focusing on vortex electron impact scattering and ionization of atoms and molecules investigate the intricate interactions between charged particles and matter, shedding light on the fundamental processes that drive atomic and molecular dynamics in the realm of quantum mechanics. By exploring the complex mechanisms of vortex electron impact, researchers aim to gain deeper insights into the behavior of atoms and molecules under external influence, ultimately contributing to the advancement of theoretical models in the field of atomic and molecular physics. (Physics)
Enriching Unnatural Amino Acids (UAAs) Toolkit via Transition-metal Catalyzed Site Selective Functionalization/Annulation of Distal C(sp2)-H bonds
28/10/2021
Inventors: Rajeev Sakhuja
In our research, we aim to enhance the repertoire of Unnatural Amino Acids (UAAs) by developing a sophisticated toolkit through the innovation of Transition-metal Catalyzed Site Selective Functionalization and Annulation. Our primary focus lies in the strategic transformation of distal C(sp2)-H bonds to achieve targeted modifications of amino acids. This...
In our research, we aim to enhance the repertoire of Unnatural Amino Acids (UAAs) by developing a sophisticated toolkit through the innovation of Transition-metal Catalyzed Site Selective Functionalization and Annulation. Our primary focus lies in the strategic transformation of distal C(sp2)-H bonds to achieve targeted modifications of amino acids. This cutting-edge approach not only broadens the scope of synthetic chemistry but also paves the way for novel applications in drug discovery, materials science, and chemical biology. Our goal is to revolutionize UAA synthesis and utilization by leveraging the power of transition-metal catalysis and precise site-specific functionalization. (Chemistry)
Structured Dialogues for Sustaibable Urban Water Management (SDSUWM)
28/11/2019
Inventors: Rajiv Gupta
Structured Dialogues for sustainable urban water management (SDSUWM) serve as a platform for engaging diverse stakeholders, including government bodies, environmental groups, and the public, in collaborative discussions aimed at finding innovative solutions to water-related challenges in urban areas. These dialogues encourage knowledge-sharing, facilitate the exchange of best practices, and promote...
Structured Dialogues for sustainable urban water management (SDSUWM) serve as a platform for engaging diverse stakeholders, including government bodies, environmental groups, and the public, in collaborative discussions aimed at finding innovative solutions to water-related challenges in urban areas. These dialogues encourage knowledge-sharing, facilitate the exchange of best practices, and promote cooperation among different sectors to achieve more efficient and environmentally friendly water management strategies. By fostering open communication and participation, SDSUWM initiatives help build consensus, raise awareness about the importance of sustainable water practices, and contribute to the overall resilience and well-being of urban communities. (Civil Engineering)
Social Media Socialization and Self-engagement: A Qualitative Study of Online Identity Reconstruction
28/03/2023
Inventors: Anupam Yadav
In this qualitative study titled "Social Media Socialization and Self-engagement," we delve into the intricate process of online identity reconstruction. By exploring how individuals interact and engage with various social media platforms, we aim to uncover the ways in which self-perception is shaped in the digital realm. Through qualitative analysis,...
In this qualitative study titled "Social Media Socialization and Self-engagement," we delve into the intricate process of online identity reconstruction. By exploring how individuals interact and engage with various social media platforms, we aim to uncover the ways in which self-perception is shaped in the digital realm. Through qualitative analysis, we seek to understand the impact of social media on personal identity formation and how individuals navigate the complexities of presenting themselves online. This research sheds light on the evolving landscape of socialization in the digital age and provides insights into the role of online platforms in shaping our identities. (Humanities & Social Sciences)
Design, Synthesis, and Evaluation of novel Dual Inhibitors of Angiotensin-II type 1 Receptor and Neprilysin for the treatment of Diabetic Cardiomyopathy
28/08/2023
Inventors: Hemant Jadhav, Gaikwad Anil Bhanudas
The overarching goal of this research project is to meticulously craft, synthesize, and meticulously evaluate groundbreaking novel dual inhibitors targeting both the Angiotensin-II type 1 receptor and Neprilysin. These innovative inhibitors are being developed with a specific focus on addressing the complex issue of diabetic cardiomyopathy, a serious condition that...
The overarching goal of this research project is to meticulously craft, synthesize, and meticulously evaluate groundbreaking novel dual inhibitors targeting both the Angiotensin-II type 1 receptor and Neprilysin. These innovative inhibitors are being developed with a specific focus on addressing the complex issue of diabetic cardiomyopathy, a serious condition that affects the heart muscle in diabetic patients. By combining the unique properties of these inhibitors, our aim is to provide a potential therapeutic solution that can effectively target multiple pathways implicated in diabetic cardiomyopathy, ultimately offering new hope for improved treatment outcomes in patients suffering from this debilitating condition. (Pharmacy)
Development of a Resonant Glucose Sensor prototype using Smart Hydrogels
29/12/2023
Inventors: Yenuganti Sujan, Pankaj Arora
The project involves the meticulous development of a cutting-edge resonant glucose sensor prototype that leverages the innovative capabilities of smart hydrogels. By integrating advanced technology with the unique properties of these materials, the sensor aims to provide a sophisticated and reliable means of monitoring glucose levels. This interdisciplinary approach combines...
The project involves the meticulous development of a cutting-edge resonant glucose sensor prototype that leverages the innovative capabilities of smart hydrogels. By integrating advanced technology with the unique properties of these materials, the sensor aims to provide a sophisticated and reliable means of monitoring glucose levels. This interdisciplinary approach combines expertise in sensor design and biomaterials, offering a promising solution for accurate and continuous glucose sensing in various applications. Through meticulous research and experimentation, this prototype seeks to pave the way for more efficient and accessible glucose monitoring tools that can significantly impact healthcare and improve quality of life. (EEE)
Development of a Tumor-Microenvironment Responsive, Cancer Theranostic Nanodots for Photodynamic-Immunotherapy
29/08/2023
Inventors: Aniruddha Roy, I R Laskar .
In this cutting-edge research project, scientists are focused on creating highly innovative nanodots that can respond to the tumor microenvironment, with the primary goal of enhancing cancer treatment efficacy through a combination of photodynamic therapy and immunotherapy. These nanodots are designed to not only target cancer cells accurately but also...
In this cutting-edge research project, scientists are focused on creating highly innovative nanodots that can respond to the tumor microenvironment, with the primary goal of enhancing cancer treatment efficacy through a combination of photodynamic therapy and immunotherapy. These nanodots are designed to not only target cancer cells accurately but also to activate a specific response within the immune system to potentially boost the overall anti-tumor effects. This interdisciplinary approach holds great promise in revolutionizing cancer therapeutics by providing a multifaceted treatment option that can adapt to the unique characteristics of individual tumors, ultimately leading to more successful outcomes for patients battling cancer. (Pharmacy)
Discovery and Biological Evaluation of Novel Dual Inhibitors of DprE1 and InhA as Potential Anti Tubercular Agents
29/08/2023
Inventors: S Murugesan
The process of discovery, along with subsequent biological evaluation, has led to the identification of innovative compounds that exhibit dual inhibitory activity against both DprE1 and InhA enzymes. These compounds are being investigated for their potential as effective anti-tubercular agents, demonstrating promise in the fight against tuberculosis. The research involved...
The process of discovery, along with subsequent biological evaluation, has led to the identification of innovative compounds that exhibit dual inhibitory activity against both DprE1 and InhA enzymes. These compounds are being investigated for their potential as effective anti-tubercular agents, demonstrating promise in the fight against tuberculosis. The research involved in uncovering these dual inhibitors marks a significant advancement in the development of novel therapeutic approaches for combating this infectious disease. (Pilani Institute wide)
An Institute of Eminence
