Description:
The inventions is related to the development of a polymeric micellar system for glutathione-mediated intracellular delivery of a photosensitizer, chlorin e6 (Ce6) by synthesizing an amphiphilic polymer, methoxy-poly(ethylene glycol)-poly(D,L-lactide) disulfide-Ce6 (mPEG-PLA-S-S-Ce6) which self assembled in aqueous environment to form micelles. The nanocarrier system for faster drug release and enhanced therapeutic effect. The GSH-mediated intracellular drug delivery was studied against mouse mammary carcinoma cells (4 T1) and human alveolar adenocarcinoma cells (A549) by pretreatment of the cells with either buthionine sulfoximine (BSO) or, glutathione monoester (GSH-OEt) thus increasing or decreasing the GSH concentration in the cytoplasm

Key Features & Benefits:

• Micellar form of Ce6 improves solubility, and stability, and cellular absorption, and passive tumor targeted delivery of Ce6 reducing non specific side effects.
• mPEG-PLA-S-S-Ce6 polymeric micelles are a surprisingly effective redox responsive system for Ce6 mediated photodynamic therapy.

Innovator(s):
Swati Biswas, Balaram Ghosh, Preeti Kumari, Department of Pharmacy, Birla Institute of Technology and Science - Pilani, Hyderabad Campus

Potential Application& Industries:
We would promote the application of this drug delivery system to pharmaceutical companies working in the development of nano formulations for cancer therapy. However, based on the interest of the pharmaceutical industry/customer on certain cancer and certain chemotherapeutic agent, our drug delivery system will be validated in other animal models, or advanced to the next level.

Patent Status: Granted

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:3

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Technology Description:

• This invention is an amalgam of hardware and software systems, the developed hardware will be used to acquire the quality images whereas the developed software will process the captured images to get the desired output.
• Hardware contains two 4MP industrial cameras, with an opal-frosted white acrylic sheet which is supported by backlit LEDs with adjustable light intensity, silver foil on the enclosed side.
• From the software point of view – the overall processing is divided into two broad categories based on the techniques used. One category is based on image processing and the other is based on application of deep learning algorithm.

Key Features & Benefits:

• It will be helpful in identifying the assembly fastening elements with higher accuracy and less time.
• It will also be useful in finding the dimensions (length, width/diameter and pitch) of fastening components.
• It will also be useful for approving and keeping the record of all the fastening elements entering different levels of assembly integration

Innovators: Faisal Mushtaq, Kaki Ramesh, Sandip Shridharrao Deshmukh, Chandu Parimi, Tathagata Ray, Praveen Tandon, Pramod Jha (Jointly filed by DRDO and Mechanical Engineering, BITS Pilani, Hyderabad Campus)

Potential Application & Industries:Mechanical and Manufacturing industries

Patent Status:Filed in India

Patent #: 202111054493

Is proof-of-concept (PoC) available? Yes

Current TRL Level:TRL-

Description:
The present invention relates to a biodegradable ocular patch for treating eye infections and a method of preparing the same.

Key Features & Benefits:

• The product of the present invention overcomes the stability issues of amphotericin
• It enables sustained drug release to reduce the frequency of administration
• Increase patient compliance

Innovator(s):
Nirmal Jayabalan, Velmurugan Kailasam, Prashant Garg., Department of Pharmacy, Birla Institute of Technology and Science - Pilani, Hyderabad Campus

Potential Application& Industries:

• The formulation can be used for ocular diseases
• Scalable for industries

Patent Status: Filed

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:3

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Description:
A nanomicellar formulation loaded with natamycinto treat ocular fungal infection. Nanomicelles improve the solubility as well as permeation of natamycin across cornea.

Key Features & Benefits:

• Improving the corneal permeation and solubility of natamycin.
• Reducing dose and dosing frequency.
• Hence, improving patient compliance.

Innovator(s):
Nirmal, Jayabalan, Priyadarshini Sathe, Velmurugan Kailasam, Prashant Garg

Department & Campus:
Pharmacy, Hyderabad

Potential Application& Industries:

• Method of preparation have potential for large scale production.
• The formulation can be used to treat ocular fungal infections.

Patent Status:Provisional patent filled

Patent #:IN202111058586

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:3

Description:
The present invention relates to a system and method for determining viscosity of a fluid and more particularly to a microfluidic based system and method for determining viscosity of a fluid.

Key Features & Benefits:

Analytical tools for the biological and chemical sciences

Innovator(s):
Sanket Goel and Puneeth S B, Department & Campus: EEE, Hyderabad Campus

Potential Application:

• Handheld and portable with miniaturized electronics
• For monitoring adulteration of various fluids

Potential Industries:

• Automobiles industry
• Healthcare sector
• Food / Milk industry

Validation & Trials Conducted:Trials conducted on milk, and automobile fuel Samples

Patent Status:Filed (India)

Patent #:201711031122

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:4

Description:
Microfluidic electro-viscometer to determine the relative viscosity of a fluid. The invention also relates to a process for preparing the microfluidic electro-viscometer to determine the relative viscosity of a fluid and also a method of determining the relative viscosity of a sample fluid.

Key Features & Benefits:

Analytical tools for the biological and chemical sciences

Innovator(s):
Sanket Goel and Puneeth S B, Department & Campus: EEE, Hyderabad Campus

Potential Application:

• Handheld and portable with miniaturized electronics
• For monitoring adulteration of various fluids

Potential Industries:

• Automobiles industry
• Healthcare sector
• Food / Milk industry

Validation & Trials Conducted:Trials conducted on milk, and automobile fuel Samples

Patent Status:Filed (India)

Patent #:201711031122

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:5

Description:
To develop an IoT driven portable microthermofluidic system for synthesizing MnO2 nanoparticles with an microfluidic platform. This thermal management system can be used as universal device for biochemical and biomedical POCT applications.

Key Features & Benefits:

• Temperature sensitivity of ±0.2°C
• Low Power ~12V
• Smartphone enabled IoT system
• POCT device

Innovator(s):
Sanket Goel, Madhusudan B Kulkarni and Yashas, Department & Campus:EE, BITS Pilani, Hyderabad campus

Potential Application

• Nanomaterial Synthesis
• DNA Amplification – PCR LAMP RPA
• Protein Denaturation
• Biochemical Process

Potential Industries:

• Pharmaceutical
• Healthcare
• Agriculture and Food
• Chemical\Clinical laboratories
• Diagnostic laboratories

Any relevant data for marketing:Fully integrated, automated and miniaturized microthermofluidic system validated and compared to benchtop instrument

Patent Status:Filed India

Patent #:202011017181

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:5

Description:
The present invention relates to a device for making designs on a substrate.

Key Features & Benefits:

Reduction in errors caused due to manual pencil graphite deposition and improve repeatability of fabricated paper-based devices

Innovator(s):
Lanka Tata Rao, Arshad Javed, Satish Kumar Dubey and Sanket Goel, Department of Mechanical Engineering & Department of Electronics & Electrical Engineering, Birla Institute of Technology & Science - Pilani, Hyderabad Campus

Potential Application

• Medical Diagnostics
• Miniaturized fuel cell
• LIF sensors

Potential Industries:

Point-of-care systems industry

Patent Status: Filed (India)

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:5

Any other relevant information :
Fully developed and trails conducted

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Description:
A wearable Electronic Nasal Air Filter for daily protection from air pollution and pollutants

Key Features & Benefits:

• An inexpensive process for monitoring and detection of pollutants
• A wearable Electronic Nasal Air Filter for daily protection from air pollution and pollutants
• Easy to plug and handle for the quantification

Innovator(s):
Avinash Kothuru and Sanket Goel, Department of Electronics & Electrical Engineering, Birla Institute of Technology and Science - Pilani, Hyderabad Campus

Potential Application & Industries:

• Economical and scalable fabrication of wearable fuel cells and sensors
• Capable of use for wearable sensing applications along with fuel cell applications

Patent Status: Pending/India

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:4

Any other relevant information :

• Fully integrated and miniatureized device,
• Lab validated

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Description:
Low-cost, ultraportable, microfluidic colorimetric device for point of care application to quantify and monitor environmental and biological analytes.

Key Features & Benefits:

• Plug and Play for Multiplexed Detection
• Integrated microfluidic chip for enhanced and highly repeatable colorimetric detection
• Portable Colorimetric Sensor

Innovator(s):
Abhishesh Pal, Madhudusan B. Kulkarni, Ponnalagu R. N., Satish K Dubey & Sanket Goel, Department of Mechanical Engineering, Birla Institute of Technology & Science - Pilani, Hyderabad Campus

Potential Application:

• Soil and Water Parameter Quantification
• Biological Chromophores

Potential Industries:

• Soil Testing and Analysis
• Point of Care Bioanalysis Testing Kits

Patent Status: Filled in India

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:5

Any other relevant information :

• The device was tested to quantify Phosphate and Nitrite using colorimetric detection
• Validation was carried out using standard spectrophotometer at peak absorption wavelength

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Description:
Enzymatic biofuel cells have attracted significant interest attributable to the simplicity and most recent key advancement made in the field of point of source(POS) and Point of care (POC) device development. This invention is an accurate electrode fabrication on paper for sensing, energy harvesting, and flexible electronics applications.

Key Features & Benefits:

• Making automated pencil strokes bioelectrodes for enzyme electrodes which can be used for instant energy harvesting from biofludies.
• Economic and disposable paper-based electrodes
• Developed bioelectrodes can be used as both sensing and powering source.

Innovator(s):
Jayapiriya U S and Sanket Goel,Department & Campus:EEE & BITS Pilani, Hyderabad campus

Department & Campus:
Pharmacy, Hyderabad

Potential Application & Industries:

• Economical and scalable fabrication of wearable fuel cells and sensors.
• Capable of use for wearable sensing applications along with fuel cell applications.

Any other relevant information/data :Fully integrated, automated and miniaturized device lab validated.

Patent Status:Filed in India

Patent #:202111017427

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:4

Description:
Useful for the treatment of Parkinson's disease and other disorders for which dopamine monitoring is therapeutically useful. A reusable polymeric 3D printed leak-proof sample chamber with a slot for the insertion of a disposable mini cartridge with an easy and quick manufacturing technique is developed. It shows low detection limit, good reproducibility, and fast response.

Key Features & Benefits:

• Point of care (POC)
• Rapidity, simplicity
• Performing diagnostics near the healthcare facility

Innovator(s):
Sanket Goel, S K Sahoo, and Mrunali Wagh,Department & Campus:EEE, Hyderabad Campus

Department & Campus:
Pharmacy, Hyderabad

Potential Application:

• Sensing of multiple analytes in biological fluids
• Simultaneously biological Sample Analysis

Potential Industries:
Medical Diagnostics

Validation & Trials Conducted:

• Trials conducted on biological Samples
• LoD —> 0.47 µM

Patent Status:Filed (India)

Patent #:202111059663

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:4

Description:
A novel liposomal formulation of Bruton’s Tyrosine Kinase (BTK) inhibitor, ibrutinib, is developed with possible enhancement in effectiveness for intended clinical application. The developed surface modified liposomal formulation is based on the application of drug (Ibrutinib) encapsulation within lipid vesicles. Moreover, the stability of this formulation would be further improved by developing a suitable robust lyophilization recipe.

Key Features & Benefits:

Development of stable liposomal formulation of Ibrutinib for increased bioavailability and reduced off- target toxicity. Additionally, modifying the surface of the liposome using a polymer would further enhance the activity and longevity of the drug.

Innovator(s):
Dr. Akash Chaurasiya, Ms. Kanan Panchal, Department of Pharmacy, Birla Institute of Technology & Science - Pilani, Hyderabad Campus

Potential Application & Industries:

Development of an effective, robust and stable formulation with high reproducibility.

Patent Status: Filled in India

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:

Any other relevant information :
Approvals/Compliances met / Validation/trials conducted

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Description:
Proposed novel formulation consists of mixture of oil(s) (like Clove oil, Cinnamon oil, etc.), surfactant(s), and co-surfactant(s) which facilitates solubilization/dissolution and absorption of posaconazole in gastrointestinal tract, when administered through oral route. This isotropic mixture of oil, surfactant, and co-surfactant enhances the bioavailability of the loaded drug in different ways, such as stimulating lymphatic transport, prolonging its GI residence time, increasing intestinal wall permeability, reducing its efflux in GIT, stimulating body secretion, etc.

Key Features & Benefits:

Application of suitable combination of surfactant and co-surfactant in optimized amount, stabilizes the formulation, facilitate drug solubilization, and thereby plays vital role in bioavailability enhancement and possess suitable therapeutic application in fungal infections. The manufacturing technique is simple, easy to scaleup, cost-effective.

Innovator(s):
Dr. Akash Chaurasiya, Mr. Sumeet Katke, Ms.Kanan Panchal, Department of Pharmacy, Birla Insitute of Technology & Science - Pilani, Hyderabad Campus

Patent Status: Filled in India

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:

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Description:
The present invention relates to a device with double-sided herringbone structures for enrichment of CAR-T cells using a continuous-flow microfluidic device.

Key Features & Benefits:
The final design provides a microfluidic device comprising of

• 2 pairs of hexagonal channels connected via 1 inlet and 2 outlets
• The herring-bone structure is being utilized to optimize cell capture and retention within the individual channels.

Benefits include that:

• They require less reagents and samples as input, cutting down a huge cost interms of device maintenance and operations.
• They are easily portable and can be used on-field.
• Easier to handle.
• They are made of polymer, hence function like a throughput device and can also be reused multiple times.
• Being smaller in size, they require less space for storage.
• user friendly.
• Being small in size and made of relatively cheap material, the cost of production of these devices is low.

Innovator(s):
Jegatha Nambi Krishnan, Prasanna Gururaj Joshi, Arya Agarwal, Rai Divakar, Hegde Ritvik, Singh Sarthak, Department of Chemical Engineering, Birla Institute of Technology and Science - Pilani, K K Birla Goa Campus

Potential Application & Industries:

The primary application of the invention will be ‘Monitoring the CAR-T cells in a Clinical Setting’. This is a necessary function in order to ensure the viability of the cells before transfusing them into the patient’s body for treatment

Patent Status: Filled in India

Patent#: 202111058598

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:3

Any other relevant information :
The profiles for pressure, velocity along with the particle trajectory within blood for the device have been obtained using COMSOL Multiphysics.

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Description:
A treatment process for cellulose based geotextile process

Key Features & Benefits:

• Over existing technology solutions
• A process for treating a cellulose based geotextile fiber comprising the steps of:
• Preparing an aqueous alkaline solution;
• Reacting coal combustion by product with the solution of
• to obtain a polymerized blend; and Applying the blend obtained in
• to the geotextile fiber.

Innovator(s):
Anasua GuhaRay, Arkamitra Kar and Shashank Gupta, Department of Civil Engineering, Birla Institute of Technology & Science - Pilani, Hyderabad Campus

Potential Application & Industries:

Improvement of durability of natural geotextiles, to be used for sustainable construction of reinforced foundation beds, slope stability etc.

Patent Status: Filled in India

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:8

Any other relevant information :
Successful trials conducted at laboratory level

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Description:
A novel material which can be used an alternative to existing biomaterials in the field of orthopaedic and dental implants and the manufacturing method for the same.

Key Features & Benefits:

Over existing implant biomaterials, our novel material possess material properties closer to the natural bone in addition to being biocompatible and bioactive. Young's modulus of natural bone is 10.4 GPa (standard deviation : 3.5), whereas it is 7GPa (standard deviation : 0.5) for our biomimetic composite. Hydroxyapatite (HA) as one of the constituents of the material makes the material bioactive while all other constituents are biocompatible.

Innovator(s):
Kulkarni Dhananjay Madhukar, Iniyan Thiruselvam N, Mali Kiran Dinkar, Savio DSA Lourenco, Department of Mechanical Engineering, Birla Institute of Technology and Science - Pilani, K K Birla Goa Campus

Potential Application & Industries:

Dental & Orthopedic implants

Patent Status: Pending

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:4

Any other relevant information :
Preliminary material testing is over

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Description:
A low-cost synthetic media combination for higher biomass growth of microalgae culture coupled with higher net lipid productivity; The high cost in microalgae-based biodiesel has constrained the economic competitiveness and significantly restricted their industrialization. To achieve commercialization of a process for producing valuable products based on microalgae, it is important to enhance the growth rate of microalgae and reducing the cost for cultivation

Key Features & Benefits:

• Low cost nutrient medium
• Increasing the lipid content
• Reducing the cost of biodiesel production

Innovator(s):
Sama Sanghamitra, Sandip Shridharrao Deshmukh, Kumar Pranav Narayan, Department of Mechanical Engineering, Birla Institute of Technology and Science - Pilani, Hyderabad Campus

Potential Application & Industries:

• A low cost synthetic media combination for higher biomass growth of microalgae culture coupled with higher net lipid productivity.
• Low cost Biodiesel production
• Commercializing the microalgae biomass production and biodiesel production.

Patent Status: Filed

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:4

Any other relevant information :
Preliminary material testing is over

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Description:
iSTAR® is an anaerobic reactor technology developed for efficient biomethanation of organic waste.

Key Features & Benefits:
STAR® has the following unique features of single-stage anaerobic digestion:

• Maintains homogeneous substrate concentration in the reactor
• Maintains uniform temperature throughout the reactor
• Continuously monitors critical parameters of the reactor
• Reduces overall energy consumption of the system

Innovator(s):
Sankar Ganesh Palani, Department of Biological Sciences, Birla Institute of Technology and Science - Pilani, Hyderabad Campus

Potential Application & Industries:

• Treatment of organic (solid and liquid) wastes
• Bioreactor fabricating and waste & wastewater treatment industries

Patent Status: Filed in India

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:7

Any other relevant information/data (non-proprietary) for marketing:

• Ready to launch at industry-scale
• Ideal for urban & rural local bodies, restaurants, institutions and gated communities
• Subsidy on capital cost from Ministry of New and Renewable Energy, Government of India

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Description:
An antenna for ultrawideband bandwidth (2 GHz-20 GHz), useful for low-power and high-power applications. The antenna has high gain (20 dB) and compact structure.

Key Features & Benefits:
Over existing technology solutions:

• Highly compact antenna
• Light weight structure
• Ultra-wideband frequency

Innovator(s):
Ashish Chittora, Swati Varun Yadav, Department of Electronics & Electrical Engineering, Birla Institute of Technology & Science - Pilani, K K Birla Goa Campus

Potential Application & Industries:

• Ground penetrating radar
• Microwave imaging
• UWB systems

Patent Status: Filed in India

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:3

Any other relevant information/data (non-proprietary) for marketing:
Prototype developed, experimentally validated in lab.

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Description:
This invention relates to a chemotherapeutic composition for treating malignant tumors comprising suberoylanilide hydroxamic acid (SAHA) entrapped in polymeric micelle comprising multiple copolymers of polyethylene glycol (PEG) and polylactide-co-glycolic acid (PLGA). The invention also relates to a method of preparing the said composition.

Key Features & Benefits:

• A chemotherapeutic composition for treating malignant tumors comprising suberoylanilide hydroxamic acid (SAHA) entrapped at the hydrophobic core of a polymeric micelle, encapsulation efficiency being between 70-100%, the micelle being 50 to 250 nm in size and comprising multiple copolymers of polyethylene glycol (PEG) and polylactide-co-glycolic acid (PLGA), the copolymers clustering together at their hydrophobic PLGA ends to form polymeric micelles, each copolymer comprising one amine-terminated PEG molecule coupled to one acid-terminated PLGA molecule resulting in an amphiphilic copolymer PEG-PLGA.
• Polymeric micelles improved aqueous solubility and enhanced anti-tumor activity and cytotoxicity in vitro and in vivo when compared to free form of SAHA.

Innovator(s):
Swati Biswas, Balaram Ghosh, Vishnu Kiran Rompicharla, Department of Pharmacy, Birla Institute of Technology & Science - Pilani, Hyderabad Campus.

Potential Application & Industries:

We would promote the application of this drug delivery system to pharmaceutical companies working in the development of nano formulations for cancer therapy.

Patent Status: Published

Patent #: (Application no 201711028012)

Is proof-of-concept (PoC) available? : Yes

Current TRL Level:4

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